Skip to main content
Log in

Mercury burden of human fetal and infant tissues

  • Original Paper
  • Published:
European Journal of Pediatrics Aims and scope Submit manuscript

Abstract

The total mercury concentrations in the liver (Hg-L), the kidney cortex (Hg-K) and the cerebral cortex (Hg-C) of 108 children aged 1 day-5 years, and the Hg-K and Hg-L of 46 fetuses were determined. As far as possible, the mothers were interviewed and their dental status was recorded. The results were compared to mercury concentrations in the tissues of adults from the same geographical area. The Hg-K (n = 38) and Hg-L (n = 40) of fetuses and Hg-K (n = 35) and Hg-C (n = 35) of older infants (11–50 weeks of life) correlated significantly with the number of dental amalgam fillings of the mother. The toxicological relevance of the unexpected high Hg-K of older infants from mothers with higher numbers of dental amalgam fillings is discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

Hg-C :

total mercury concentration in the cerebral cortex (ng/g wet weight)

Hg-K :

total mercury concentration in the renal cortex (ng/g wet weight)

Hg-L :

total mercury concentration in the liver (ng/g wet weight)

References

  1. Aposhian HV, Bruce DC, Alter W, Dart RC, Hurlbut KM, Aposhian MM (1992) Urinary mercury after administration of 2,3-dimercaptopropane-l-sulfonic acid: correlation with dental amalgam score. FASEB J 6: 2472–2476

    Google Scholar 

  2. Boyd ND, Benediktsson H, Vimy MJ, Hooper DE, Lorscheider FL (1991) Mercury from dental “silver” tooth fillings impairs sheep kidney function. Am J Physiol 261: R 1010-R 1014

    Google Scholar 

  3. Bundesgesundheitsamt (1992). bga-Informationsschrift “Amalgame in der zahnärztlichen Therapie”. Berlin

  4. Drasch G, Kretschmer E, Neidlinger P, Summer KH (1989) Cadmium, zinc, copper and methallothionein in human tissues (liver and kidney). Toxicol Environ Chem 23: 207–214

    Google Scholar 

  5. Drasch G, Schupp I, Riedl G, Günther G (1992) Einfluß von Amalgamfüllungen auf die Quecksilberkonzentration in menschlichen Organen. Dtsch Zahnärztl Z 47: 490–496

    Google Scholar 

  6. Goering PL, Galloway WD, Clarkson TW, Lorscheider FL, Berlin M, Rowland AS (1992) Toxicity assessment of mercury vapor from dental amalgams. Fund Appl Toxicol 19: 319–329

    Google Scholar 

  7. Horvat M, Stegnar P, Byrne AR, Dermelj M, Branica Z (1988) A study of trace elements in human placenta, blood and hair from the yugoslav central adriatic. In: Brätter P, Schramel P (eds) Trace elements analytical chemisty in medicine and biology, vol. 5. de Gruyter, Berlin, pp 243–250

    Google Scholar 

  8. Klein D, Scholz P, Drasch G, Müller-Höcker J, Summer KH (1991) Metallothionein, copper and zinc in fetal and neonatal human liver: changes during development. Toxicol Lett 56: 61–67

    Google Scholar 

  9. Klemann D, Weinhold J, Strubelt O, Pentz R, Jungblut JR, Kleik F (1990) Der Einfluß von Amalgamfüllungen auf die Quecksilberkonzentrationen in Fruchtwasser und Muttermilch. Dtsch Zahnärztl Z 45: 142–145

    Google Scholar 

  10. Koos BJ, Longo LD (1976) Mercury toxicity in the pregnant woman, fetus and newborn infant. Am J Obstet Gynecol 126: 390–409

    Google Scholar 

  11. Larsson KS (1991) Tereatological aspects of dental amalgam. Adv Dent Res 6: 114–119

    Google Scholar 

  12. Larsson KS, Sagulin G-B (1990) Placental transfer of mercury from amalgam. Lancet 336: 1251

    Google Scholar 

  13. Lorscheider FL, Vimy MJ (1990) Mercury from dental amalgam. Lancet 336: 1578–1579

    Google Scholar 

  14. Markesbery WR, Ehmann WD, Alauddin M, Hussain TIM (1984) Brain trace element concentration in aging. Neurobiol Aging 5: 19–28

    Google Scholar 

  15. Mottet NK, Body RL (1974) Mercury burden of human autopsy organs and tissues. Arch Environ Health 29: 18–24

    Google Scholar 

  16. Nishimura H, Hirota S, Tannaka O, Ueda M, Uno T (1974) Normal mercury level in human embryos and fetuses. Biol Neonate 24: 197–205

    Google Scholar 

  17. Nordberg GF (1989) Modulation of metal toxicity by metallothionein. Biol Trace Elem Res 21: 131–135

    Google Scholar 

  18. Nylander M, Weiner J (1991) Mercury and selenium concentrations and their inter-relationship in organs from dental staff and the general population. Br J Ind Med 48: 729–734

    Google Scholar 

  19. Schupp I (1994) Untersuchungen an menschlichen Organen zur Frage der Quecksilberbelastung durch Zahnamalgam und weitere Faktoren. Dissertation, München, F.R.G.

  20. Suzuki T, Yonemoto J, Satoh H, Naganuma A, Imura N, Kigawa T (1984) Normal organic and inorganic mercury levels in the human feto-placental system. J Appl Toxicol 4: 249–252

    Google Scholar 

  21. Thorp JM, Boyette DD, Watson WJ, Cefalo RC (1992) Elemental mercury exposure in early pregnancy. Obstet Gynecol 79: 874–876

    Google Scholar 

  22. Vimy MJ, Takahashi, Y, Lorscheider FL (1990) Maternal-fetal distribution of mercury (203Hg) released from dental amalgam fillings. Am J Physiol 258: R939-R945

    Google Scholar 

  23. Von Mühlendahl KE (1990) Intoxication from mercury spilled on carpets. Lancet 336: 1578

    Google Scholar 

  24. WHO (1991) Environmental Health Criteria 118: Inorganic Mercury. World Health Organization, Geneva

    Google Scholar 

  25. Yoshida M, Aoyama H, Satoh H, Yamamura Y (1987) Binding of mercury to metallothionein-like protein in fetal liver of the guinea pig following inutero exposure to mercury vapor. Toxicol Lett 37: 1–6

    Google Scholar 

  26. Yoshida M, Satoh H, Kojima S, Yamamura Y (1989) Distribution of mercury in neonatal guinea-pigs after the exposure to mercury vapours. Bull Environ Contam Toxicol 43: 697–704

    Google Scholar 

  27. Zinke T (1992) Amalgame in der zahnärztlichen Therapie. Bundesgesundhbl 35:613–616

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Drasch, G., Schupp, I., Höfl, H. et al. Mercury burden of human fetal and infant tissues. Eur J Pediatr 153, 607–610 (1994). https://doi.org/10.1007/BF02190671

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02190671

Key words

Navigation