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Immunohistochemical and clinical evaluation of cathepsin expression in soft tissue sarcomas

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Abstract

Lysosomal proteases are known to enhance the spread of epithelial tumour cells, but little is known of the possible role of proteases in the growth of soft tissue sarcomas (STS). We investigated the expression of cathepsins D, B, S, H, L and procathepsin L in frozen sections of 34 STS from 34 patients by immunohistochemistry (IHC). Cathepsins D, B and H were relatively highly expressed in STS (77–91%). The expression rate of cathepsins S and L and of procathepsin L was lower (40–66%). Cathepsin S and L expression showed a moderate (P = 0.078 andP = 0.019) and procathepsin L a strong (P = 0.00001) correlation with the survival rate of STS patients. Cathepsin S expression is also correlated with the local recurrence rate (P < 0.01). Lysosomal proteases may play a role in STS progression, and cathepsin expression may also have, significance as a prognostic factor in STS.

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Authors and Affiliations

  1. Clinic of General Surgery, Martin-Luther-University of Halle-Wittenberg, Germany

    Peter Würl & Henning Dralle

  2. Institute of Pathology, Martin-Luther-University of Halle-Wittenberg, Magdeburger Strasse 14, D-06097, Halle/S., Germany

    Helge Taubert, Axel Meye, Temuujin Dansranjavin, Dieter Berger, Hannelore Schmidt & Friedrich-Wilhelm Rath

  3. Institute of Physiological Chemistry, Martin-Luther-University of Halle-Wittenberg, Germany

    Ekkehard Weber & Dagmar Günther

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  1. Peter Würl
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Würl, P., Taubert, H., Meye, A. et al. Immunohistochemical and clinical evaluation of cathepsin expression in soft tissue sarcomas. Virchows Archiv 430, 221–225 (1997). https://doi.org/10.1007/BF01324805

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  • DOI: https://doi.org/10.1007/BF01324805

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