Abstract
The disruptive effect of meals of different fat content and caloric value and of sham feeding on the interdigestive migrating motor complex (IDMMC) was studied in eight healthy subjects using an ambulatory recording system that allowed continuous monitoring of small bowel motility for three consecutive days. The durations of fed pattern were not significantly different between meals of 800 kcal/50% fat, 400 kcal/50% fat, and 800 kcal/25% fat, but were significantly longer compared to IDMMC cycle length and sham feeding. The latter two were not significantly different. On a separate day, five subjects consumed a meal of 400 kcal/9% fat and a second one of 800 kcal/50% fat. The duration of the fed pattern following the high fat meal was significantly longer than the low fat one. Sham feeding significantly increased plasma concentrations of gastrin and neurotensin (NT), but did not affect those of cholecystokinin (CCK), insulin, and peptide YY (PYY). The various variables of the IDMMC were not different during the two nights of the study, and velocity of migration of phase III during the first day and both nights was similar. We conclude that the duration of the fed pattern depends, in part, on the composition of the meal. Sham feeding, resulting in an increase in both plasma gastrin and NT concentrations, does not disrupt the IDMMC. When using thin probes, IDMMC is stable during prolonged recording.
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Code CF, Marlett JA: The interdigestive myoelectric complex of the stomach and small bowel of dogs. J Physiol (London) 246:289–309, 1975
Vantrappen G, Janssens J, Ghoos Y: The interdigestive motor complex of normal subjects and patients with bacterial overgrowth of the small intestine. J Clin Invest 59:1158–1166, 1977
Weisbrodt NW, Moore E, Kearley R, Copeland EM, Johnson LR: Effects of pentagastrin on the myoelectric activity of the small intestine. Am J Physiol 227:425–429, 1974
Mukhopadhyay AK, Thor PJ, Copeland EM, Johnson LR, Weisbrodt NW: Effect of cholecystokinin on myoelectric activity of small bowel of the dog. Am J Physiol 232:E44-E47, 1977
Thor K, Rosell S, Rokaeus A, Kager L: (Gln4)-Neurotensin changes the motility pattern of the duodenum and proximal jejunum from a fasting-type to a fed-type. Gastroenterology 83:569–574, 1982
Bueno L, Ruckebusch M: Insulin and jejunal electrical activity in dogs and sheep. Am J Physiol 230:1538–1544, 1976
Sarr MG, Kelly KA: Myoelectric activity of the autotransplanted canine jejunoileum. Gastroenterology 81:303–310, 1981
Ouyang A, Sunshine AG, Reynolds JC: Caloric content of a meal affects duration but not contractile pattern of duodenal motility in man. Dig Dis Sci 34:528–536, 1989
Beardshall K, Frost G, Morarji Y, Domin J, Bloom SR, Calam J: Saturation of fat and cholecystokinin release: Implications for pancreatic carcinogenesis. Lancet 2:1008–1010, 1989
Lee YC, Allen JM, Uttenthal LO, Roberts PM, Gill SS, Bloom SR: Quantitation and characterization of human plasma neurotensin-like immunoreactivity in response to a meal. Dig Dis Sci 30:129–133 1985
Adrian TE, Ferri G-L, Bacarese-Hamilton AJ, Fuessl HS, Polak JM, Bloom SR: Human distribution and release of a putative new gut hormone, peptide YY. Gastroenterology 89:1070–1077, 1985
Bloom SR, Long RG: Radioimmunoassay of Gut Regulatory Peptides. London, WB Saunders, 1982
Feldman M, Richardson CT, Fordtran J: Experience with sham-feeding as a test for vagotomy. Gastroenterology 79:792–795, 1980
Weiner BJ: Statistical Principals in Experimental Design, 2nd ed. New York, McGraw-Hill, 1971
Stern RM, Crawford HE, Stewart WR, Vasey MW, Koch KL: Sham feeding: Cephalic-vagal influences on gastric myoelectric activity. Dig Dis Sci 34:521–527, 1989
Fisher RS, Rock E, Malmud LS: Gallbladder emptying response to sham feeding in humans. Gastroenterology 90:1854–1857, 1986
Rogers J, Raimundo AH, Misiewicz JJ, Bloom SR: Cephalic phase of pancreatic polypeptide, motilin, and gastrin release is associated with the cephalic phase of the colonic response to food. Gastroenterology 98:A385, 1990
Ruckebusch Y, Bueno L: Migrating myoelectrical complex of the small intestine. Gastroenterology 73:1309–1314, 1977
Defilippi C, Valenzuela JE: Sham feeding disrupts the interdigestive motility complex in man. Scand J Gastroenterol 16:977–979, 1981
Giduck SA, Threatte RM, Kare MM: Cephalic reflexes: Their role in digestion and possible roles in absorption and metabolism. J Nutr 117:1191–1196, 1987
Marik F, Code CF: Control of the interdigestive myoelectric activity in dogs by the vagus nerves and pentagastrin. Gastroenterology 69:387–395, 1975
Weisbrodt NW, Copeland EM, Moore EP, Kearley RW, Johnson LR: Effect of vagotomy on electrical activity of the small intestine of the dog. Am J Physiol 228:650–654, 1965
Thompson DG, Ritchie HD, Wingate DL: Patterns of small bowel motility in duodenal ulcer patients before and after vagotomy. Gut 23:517–523, 1982
Al-Saffar A, Hellstrom PM, Nylander G: Correlation between peptide YY-induced myoelectric activity and transit of small-intestinal contents in rats. Scand J Gastroenterol 20:577–582, 1985
De Wever I, Eeckhout C, Vantrappen G, Hellemans J: Disruptive effect of test meals on interdigestive motor complex in dogs. Am J Physiol 235:E661-E665, 1978
Kellow JE, Borody TJ, Phillips SF, Tucker RL, Haddad AC: Human interdigestive motility: Variations in patterns from esophagus to colon. Gastroenterology 91:386–395, 1986
Schang JC, Daucheal J, Sava P, Angel F, Bouchet P, Lambert A, Grenier JF: Specific effects of different food components on intestinal motility. Eur Surg Res 10:425–432, 1978
Kellow JE, Gill RC, Wingate DL: Prolonged ambulant recordings of small bowel motility demonstrate abnormalities in the irritable bowel syndrome. Gastroenterology 98:1208–1218, 1990
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A preliminary report of this work was at the meeting of the American Motility Society, October 1990, and was published as an abstract in Gastroenterology 1990;99:A1232.
This study was supported by grant RR59 for General Clinical Research Center Program, Division of Research Resources, NIH.
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Soffer, E.E., Adrian, T.E. Effect of meal composition and sham feeding on duodenojejunal motility in humans. Digest Dis Sci 37, 1009–1014 (1992). https://doi.org/10.1007/BF01300279
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DOI: https://doi.org/10.1007/BF01300279