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Citalopram and 8-OH-DPAT attenuate nicotine-induced excitation of central noradrenaline neurons

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Summary

Previous electrophysiological studies have demonstrated that nicotine, intravenously administered, excites noradrenergic neurons in the locus coeruleus (LC) indirectly by releasing excitatory amino acids (EAA). In the present study the excitatory action of nicotine was inhibited by treatment with the selective 5-HT re-uptake inhibitor citalopram or the 5-HT1A receptor agonist 8-OH-DPAT. It is proposed that the antagonism between nicotine and citalopram or 8-OH-DPAT reflects an interaction between endogenous EAA, e.g. glutamate, and 5-HT. The results may, on a cellular basis, explain the attributed effectiveness of drugs that facilitate serotonergic neurotransmission in promoting smoking cessation.

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References

  • Aghajanian GK, Cedarbaum JM, Wang RY (1977) Evidence for norepinephrine-mediated collateral inhibition of locus coeruleus neurons. Brain Res 131: 570–577

    Google Scholar 

  • Aston-Jones G, Ennis M, Pieribone VA, Nickell WT, Shipley MT (1986) The brain nucleus locus coeruleus: restricted afferent control of a broad efferent network. Science 234: 734–737

    Google Scholar 

  • Aston-Jones G, Akaoka H, Charléty P, Chouvet G (1991) Serotonin selectively attenuates glutamate-evoked activation of noradrenergic locus coeruleus neurons. J Neurosci 11: 760–769

    Google Scholar 

  • Chen Z, Engberg G (1989) The rat nucleus paragigantocellularis as a relay station to mediate peripherally induced central effects of nicotine. Neurosci Lett 101: 67–71

    Google Scholar 

  • Engberg G (1989) Nicotine induced excitation of locus coeruleus neurons is mediated via release of excitatory amino acids. Life Sci 44: 1535–1540

    Google Scholar 

  • Engberg G, Svensson TH (1980) Pharmacological analysis of a cholinergic receptor mediated regulation of brain norepinephrine neurons. J Neural Transm 49: 137–150

    Google Scholar 

  • Ennis M, Aston-Jones G (1986) A potent excitatory input to the nucleus locus coeruleus from the ventrolateral medulla. Neurosci Lett 71: 299–305

    Google Scholar 

  • Ennis M, Aston-Jones G (1988) Activation of locus coeruleus neurons from the paragigantocellularis: a new excitatory amino acid pathway in brain. J Neurosci 8: 3644–3657

    Google Scholar 

  • Eriksson E, Humble M (1990) Serotonin in psychiatric pathophysiology: a review of data from experimental and clinical research. In: Pohl R, Gershon S (eds) The biological basis of psychiatric treatment. Karger, Basel, pp 66–119 (Prog Basic Clin Pharmacol, vol 3)

    Google Scholar 

  • Foote SL, Bloom FE, Aston-Jones G (1983) Nucleus locus coeruleus: new evidence of anatomical and physiological specificity. Physiol Rev 63: 844–914

    Google Scholar 

  • Gawin F, Compton M, Byck R (1989) Potential use of buspirone as treatment for smoking cessation: a preliminary trial. Fam Pract Recertification 11 [Suppl]: 74–84

    Google Scholar 

  • Gebber GL (1969) Neurogenic basis for the rise in blood pressure evoked by nicotine in the cat. J Pharmacol Exp Ther 166: 255–263

    Google Scholar 

  • Glassman AH, Covey LS (1990) Future trends in the pharmacological treatment of smoking cessation. Drugs 40: 1–5

    Google Scholar 

  • Hajos M, Engberg G (1988) Role of primary sensory neurons in the central effects of nicotine. Psychopharmacology 94: 468–470

    Google Scholar 

  • Imai H, Steindler DA, Kitai ST (1986) The organization of divergent axonal projection from the midbrain raphe nuclei in the rat. J Comp Neurol 243: 363–380

    Google Scholar 

  • Paxinos G, Watson C (1983) The rat brain in stereotaxic coordinates. Academic Press, New York

    Google Scholar 

  • Pieribone VA, Aston-Jones G (1990) Serotonergic innervation of the rat locus coeruleus. Eur J Pharmacol [Suppl] 3: 231

    Google Scholar 

  • Segal M (1979) Serotonergic innervation of the locus coeruleus from the dorsal raphe and its action on response to noxious stimuli. J Physiol (Lond) 286: 401–415

    Google Scholar 

  • Svensson TH (1987) Peripheral, autonomic regulation of locus coeruleus noradrenergic neurons in brain: putative implications for psychiatry and psychopharmacology. Psychopharmacology 92: 1–7

    Google Scholar 

  • Svensson TH, Engberg G (1980) Effect of nicotine on single cell activity in the noradrenergic nucleus locus coeruleus. Acta Physiol Scand [Suppl 479]: 31–34

    Google Scholar 

  • Tung C-S, Ugedo L, Grenhoff J, Engberg G, Svensson TH (1989) Peripheral induction of burst firing in locus coeruleus neurons by nicotine mediated via excitatory amino acids. Synapse 4: 313–318

    Google Scholar 

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  1. G. Engberg

    Present address: Department of Pharmacology, University of Göteborg, Sweden

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    1. G. Engberg
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    Engberg, G. Citalopram and 8-OH-DPAT attenuate nicotine-induced excitation of central noradrenaline neurons. J. Neural Transmission 89, 149–154 (1992). https://doi.org/10.1007/BF01250667

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    • DOI: https://doi.org/10.1007/BF01250667

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