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2,6-Diisopropylphenol, a general anesthetic, inhibits glutamate action on rat synaptosomes

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Abstract

2,6-diisopropylphenol (propofol), a general intravenous anesthetic, inhibits the glutamate-dependent Ca2+ entry in rat synaptosomes with an approximate IC50 of 3.0×10−5 M.Propofol, at concentrations above 10−6M, also inhibits the ATP-dependent uptake of glutamate in the presence of Ca2+, with an approximate IC50 of 3.5×10−5M, while it only has a slight inhibitory effect on the release of glutamate. The ouabain-insensitive synaptosomal ATPase is strongly inhibited by propofol, with an IC50 of about 2.5×10−6M, at concentrations which do not affect the luciferase system.

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  1. Department of Biological Chemistry, University of Padova, Via Trieste, 75, 35121, Padova, Italy

    M. Bianchi, T. Battistin & L. Galzigna

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  1. M. Bianchi
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  2. T. Battistin
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  3. L. Galzigna
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Bianchi, M., Battistin, T. & Galzigna, L. 2,6-Diisopropylphenol, a general anesthetic, inhibits glutamate action on rat synaptosomes. Neurochem Res 16, 443–446 (1991). https://doi.org/10.1007/BF00965564

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  • DOI: https://doi.org/10.1007/BF00965564

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