References
Abe R, Akiyoshi T, Tsuji H, Baba T (1986) Protection of antiproliferative effect ofcis-diamminedichloroplatinum(II) by sodium thiosulfate. Cancer Chemother Pharmacol 18:98–100
Aggerwal SK, Whitehouse MW, Ramachandran C (1980) Ultrastructural effects of cisplatin. In: Prestayko AW, Crooke ST, Carter SK (eds) Cisplatin: current status and new developments. Academic, New York, pp 79–111
Bell DR, Woods RL, Levi JA (1985)cis-Diamminedichloroplatinum-induced hypomagnesemia and renal magnesium wasting. Eur J Cancer Clin Oncol 21:287–290
Bernard A, Buchet JP, Rock H, Masson P, Lauwerys R (1979) Renal excretion of proteins and enzymes in workers exposed to cadmium. Eur J Clin Invest 9:11–22
Bird JE, Walse MM, Queblemann AJ (1984) Protective effect of organic cation transport inhibitors oncis-diamminedichloroplatinum induced nephrotoxicity. J Pharmacol Exp Ther 231:752–758
Bitran JP, Desser RK, Billings AA, Kozloff MF, Shapiro CM (1982) Acute nephrotoxicity followingcis-dichlorodiammineplatinum. Cancer 49:1784–1788
Brenner BM, Baylis C, Deen WM (1976) Transport of molecules across renal glomerular capillaries. Physiol Rev 56: 502–534
Bridges CR, Myers BD, Brenner BM, Deen WM (1982) Glomerular charge alterations in human minimal change nephropathy. Kidney Int 22:677–684
Buamah PK, Howell A, Whitby H, Harpur ES, Gescher A (1982) Assessment of renal function during high-dose cis-platinum therapy in patients with ovarian carcinoma. Cancer Chemother Pharmacol 8:281–284
Bucley JE, Clark UL, Meyer T, Pearlman NW (1984) Hypomagnesemia after cisplatin combination chemotherapy. Arch Intern Med 144:2347–2348
Chopra S, Kaufman JS, Jones TW, Hong WK, Gehr MK, Hamburger RJ, Flamenbaum W, Trump BF (1982)cis-Diamminedichloroplatinum-induced acute renal failure in the rat. Kidney Int 21:54–64
Clifton G, Pearce C, O'Neill W (1982) Early polyuria in the rat following single dosecis-dichloroammine platinum(II). J Lab Clin Med 100:659–670
Cohen AI, Harberg J, Citrin DL (1981) Measurement of urinary beta-2-microglobulin in the detection of cisplatin nephrotoxicity. Cancer Treat Rep 65:1083–1085
Daugaard G, Rørth M (1986) High-dose cisplatin and VP-16 with bleomycin in the management of advanced metastatic germ cell tumors. Eur J Cancer Clin Oncol 22:477–485
Daugaard G, Abildgaard U, Amtorp O (1985) Acute effect ofcis-diamminedichloroplatinum on renal blood flow and glomerular filtration rate in dogs. In: Bach PH, Lock EA (eds) Renal heterogeneity and target cell toxicity. Wiley, London, pp 401–404
Daugaard G, Abildgaard U, Holstein-Rathlou N-H, Leyssac PP, Amtorp O, Dikhoff TG (1986) Acute effect of cisplatin on renal hemodynamics and tubular function in dog kidneys. Renal Physiol 9:308–316
Daugaard G, Abildgaard U, Larsen S, Holstein-Rathlou N-H, Amtorp O, Olesen HP, Leyssac PP (1987) Functional and histopathological changes in dog kidneys after administration of cisplatin. Renal Physiol 10:54–64
Daugaard G, Strandgaard S, Holstein-Rathlou N-H, Fredriksen PL, Svendsen UG, Munck O, Leyssac PP (1987) The renal handling of sodium and water is not affected by the standard dose cisplatin treatment for testicular cancer. Scand J Clin Lab Invest 47:455–459
Daugaard G, Holstein-Rathlou N-H, Leyssac PP (1988) Effect of cisplatin on proximal convoluted and straight segments of the rat kidney. J Pharmacol Exp Ther 224: 1081–1085
Daugaard G, Rossing N, Rørth M (1988) Effects of high-dose cisplatin on glomerular function in the human kidney. Cancer Chemother Pharmacol 21:163–167
Daugaard G, Abildgaard U, Holstein-Rathlou N-H, Bruunshuus I, Bucher D, Leyssac PP (1989) Renal tubular functions in patients treated with high-dose cisplatin. Clin Pharmacol Ther (in press)
deGislain C, Dumas M, d'Athis P, Lantissier JL, Escousse A, Guerrin J (1986) Urinary β-2-microglobulin: early indicator of high dosecis-diamminedichloroplatinum nephrotoxicity? Influence of furosemide. Cancer Chemother Pharmacol 18: 276–279
Dentino M, Luft FC, Yum MN, Williams SD, Einhorn LH (1978) Long term effect ofcis-diamminedichloride platinum (CDDP) on renal function and structure in man. Cancer 41: 1274–1281
Diener U, Knoll E, Ratge D (1982) Urinary excretion of alanine aminopeptidase andN-acetyl-β-d-glucosaminidase during sequential combination chemotherapy. J Clin Chem Clin Biochem 20:615–619
Dobyan DC, Levi J, Jacobs C, Kosek J, Weiner NW (1980) Mechanism of cisplatinum nephrotoxicity: II. Morphologic observations. J Pharmacol Exp Ther 7:551–556
Doolan CP, Alpen EL, Theil GB (1962) A clinical appraisal of the plasma concentration and endogenous clearance of creatinine. Am J Med 32:65–79
Elmer M, Eskildsen PC, Kristensen Ø, Leyssac PP (1972) A comparison of renal function in rats anaesthetized with inactin and sodium amytal. Acta Physiol Scand 86:41–58
Favre HR, Wing AJ (1968) Simultaneous51Cr edetic acid, inulin and endogenous creatinine clearance in 20 patients with renal disease. Br Med J 1:84–86
Fjeldborg P, Sørensen J, Helkjær PE (1986) The long-term effect of cisplatin on renal function. Cancer 58:2214–2217
Foulkes EC, Blanck S (1982) Mechanism of inhibition of renal amino acid reabsorption in rabbits by heavy metals. Toxicol Appl Pharmacol 64:103–107
Garnett ES, Parsons V, Veall N (1967) Measurement of glomerular filtration rate in man using a51Cr/edetic-acid complex. Lancet I:818–819
Giebisch G, Windhager EE (1973) Electrolyte transport across renal tubular membranes. In: Orloff J, Berliner RW (eds) Handbook of physiology. Section 8, renal physiology. American Physiological Society, Washington, DC, p 315
Gonzales-Vitale JC, Hayes DM, Cvitkovic E, sternberg SS (1977) The renal pathology in clinical trials ofcis-platinum(II)diamminedichloride. Cancer 39:1362–1371
Goren MP, Wright RK, Horowitz ME (1986) Cumulative renal damage associated with cisplatin nephrotoxicity. Cancer Chemother Pharmacol 18:69–73
Goren MP, Forastiere AA, Wright RK, Horowitz ME, Dodge RK, Kamen BA, Viar MJ, Pratt CB (1987) Carboplatin (CBDCA), iproplatin (CHIP) and high dose cisplatin in hypertonic saline evaluated for tubular nephrotoxicity. Cancer Chemother Pharmacol 19:57–60
Groth S, Nielsen H, Sørensen JB, Christensen JB, Pedersen AG, Rørth M (1986) Acute and long-term nephrotoxicity of cis-platinum in man. Cancer Chemother Pharmacol 17: 191–196
Hacke M, Schmoll HJ, Alt JM, Baumann K, Stolte H (1983) Nephrotoxicity ofcis-diamminedichloroplatinum with or without ifosfamide in cancer treatment. Clin Physiol Biochem 1:17–26
Hayes DM, Cvitkovic E, Golber RB, Scheiner E, Helson L, Krakoff I (1977) High dosecis-platinumdiamminedichloride. Amelioration of renal toxicity by mannitol diuresis. Cancer 39:1372–1381
Higby PJ, Wallace HJ, Holland JF (1975)cis-Diamminedichloroplatinum (NSC-119875): a phase I study. Cancer Chemother Rep 59:647–659
Hill JB, Russo A (1981) Cisplatin induced hypomagnesemic hypocalcemia. Arch Intern Med 141:1100
Hilton PJ, Lavender S, Roth Z, Jones NF (1969) Creatinine clearance in patients with proteinuria. Lancet II:1215–1216
Holstein-Rathlou N-H, Christensen P, Leyssac PP (1982) Effects of halothane-nitrous oxide inhalation anaesthesia and inactin on overall renal and tubular function in Sprague-Dawley and Wistar rats. Acta Physiol Scand 114: 193–201
Howell SB, Taetle R (1980) Effect of sodium thiosulfate oncis-dichlorodiammineplatinum(II) toxicity and anti-tumor activity in L1210 leukemia. Cancer Treat Rep 64:611–616
Howell SB, Pfeifle CE, Wung WE, Olshen RA (1983) Intraperitonealcis-diamminedichloroplatinum with systemic thiosulfate protection. Cancer Res 43:1426–1431
Ishizawa M, Taniguchi S, Baba T (1981) Protection of sodium thiosulfate against lethal toxicity ofcis-diamminedichloroplatinum(II) in bacteria and mice. Jpn J Pharmacol 31: 883–889
Iwamoto Y, Kawano T, Uozumi J, Aoki K, Baba T (1984) “Two-route chemotherapy” using high-dose i.p. cisplatin and i.v. sodium thiosulfate antidote for peritoneally disseminated cancer in mice. Cancer Treat Rep 68:1367–1373
Jones BR, Bhalla RB, Mladek J, Kaleya RN, Gralla RJ, Alcock NW, Schwartz MK, Young CW, Reidenberg MM (1980) Comparison of methods of evaluating nephrotoxicity of cisplatinum. Clin Pharmacol Ther 27:557–562
Khlar S, Tripathy K (1966) Evaluation of renal function in malnutrition. Arch Intern Med 118:322–325
Kovach JS, Moertel CG, Schutt AJ (1973) Phase II study ofcis-diamminedichloroplatinum (NSC-119875) in advanced carcinoma of the large bowel. Cancer Chemother Rep 57: 337–359
Krakoff IH (1979) Nephrotoxicity ofcis-dichlorodiammineplatinum(II). Cancer Treat Rep 63:1523–1525
Lammers PJ, White L, Ettinger LJ (1984) Cis-platinum induced renal sodium wasting. Med Pediatr Oncol 12:343–346
Lavender S, Hilton PJ, Jones NF (1969) The measurement of glomerular filtration rate in renal disease. Lancet II: 1216–1219
Legha SS, Dimery IW (1985) High-dose cisplatin administration without hypertonic saline: observation of disabling neurotoxicity. J Clin Oncol 3:1373–1378
Levi J, Jacobs C, Klman SM, McTigue M, Weiner MW (1980) Mechanism of cis-platinum nephrotoxicity: I. Effect of sulfhydryl groups in rat kidneys. J Pharmacol Exp Ther 213: 545–550
Leyland-Jones B, Morrow C, Tate S, Urmacher C, Gordon C, Young W (1983)cis-Diamminedichloroplatinum(II) nephrotoxicity and its relationship to renal gamma-glutamyl transpeptidase and glutathione. Cancer Res 43:6072–6076
Litterst CL (1981) Alterations in the toxicity ofcis-dichlorodiammineplatinum(II) and in tissue localization of platinum as a function of NaCl concentration in the vehicle of administration. Toxicol Appl Pharmacol 61:99–108
Madias NE, Harrington T (1978) Platinum nephrotoxicity. Am J Med 65:307–314
Markman M, Cleary S, Howell SB (1985) Nephrotoxicity of high-dose intracavitary cisplatin with intravenous thiosulfate protection. Eur J Cancer Clin Oncol 21:1015–1018
Massry SG, Coburn JW, Chapman LW, Kleeman CR (1967) Effect of NaCl infusion on urinary calcium and magnesium during reduction in their filtered loads. Am J Physiol 213: 1218–1244
Mavichak V, Wong NLM, Quamme GA, Magil AB, Sutton RAL, Dirks JH (1985) Studies on the pathogenesis of cisplatin induced hypomagnesemia in rats. Kidney Int 28:914–921
McMurty RJ, Mitchell JR (1977) Renal and hepatic necrosis after metabolic activation of 2-substituted furans and thiophenes including furosemide and cephaloridine Toxicol Appl Pharmacol 42:285–300
Meijer S, Sleifer DT, Mulder N, Sluiter WJ, Marrink J, Koops HS, Brouwers TM, Oldhoff J, Hems GK van der, Mandema E (1983) Some effects of combination chemotherapy with cis-platinum on renal function in patients with nonseminomatous testicular carcinoma. Cancer 51:2035–2040
Miura K, Goldstein RS, Pasino DA, Hook JB (1987) Cisplatin nephrotoxicity: role of filtration and tubular transport of cisplatin in isolated perfused kidneys. Toxicology 44: 147–158
Offerman JJG, Meijer S, Sleifer DTH, Mulder NH, Donker AJM, Schrafford Koops H, Hem GK van der (1984) Acute effects ofcis-diamminedichloroplatinum (CDDP) on renal function. Cancer Chemother Pharmacol 12:36–38
Ozols RF, Cordon BJ, Jacobs J, Wesley M, Ostchega Y, Young RC (1984) High-dose cisplatin in hypertonic saline. Ann Intern Med 100:19–24
Ozols RF, Ihde DC, Linehan WM, Jacob J, Ostchega Y, Young RC (1988) A randomized trial of standard chemotherapy vs a high-dose chemotherapy regimen in the treatment of poor prognosis nonseminomatous germ-cell tumors. J Clin Oncol 6:1031–1040
Payne RB (1986) Creatinine clearance: a redundant clinical investigation. Ann Clin Biochem 23:243–250
Pera MF, Zook BC, Harder HC (1979) Effects of mannitol or furosemide diuresis on the nephrotoxicity and physiological disposition ofcis-dichloroplatinum(II) in rats. Cancer Res 39: 1269–1278
Peterson PA, Evrin PE, Berggaard I (1969) Differentiation of glomerular, tubular and normal proteinuria: determination of urinary excretion of beta-2-microglobulin, albumin and total protein. J Clin Invest 48:1189–1198
Peterson PA, Berggaard I (1971) Urinary immunoglobulin components in normal, tubular and glomerular proteinuria: quantities and characteristics of free light chains, IgG, IgA and Fc-gamma fragments. Eur J Clin Invest 1:255–264
Pfeifle CE, Howell SB, Felthouse RD, Woliver TBS, Andrews PA, Markman M, Murphy MP (1985) High-dose cisplatin with sodium thiosulfate protection. J Clin Oncol 3:237–244
Phelps JS, Gandolfi AJ, Brendel K, Dorr RT (1987) Cisplatin nephrotoxicity: in vitro studies with precision-cut rabbit renal cortical slices. Toxicol Appl Pharmacol 90:501–512
Portmans J, Bienenstock J (1975) Synthesis of immunoglobulins and 15 other proteins by diseased human kidneys. Eur J Clin Invest 5:365–371
Safirstein R, Miller P, Dikman S, Lyman S, Shapiro C (1982) Cisplatin nephrotoxicity in rats: defect in papillary hypertonicity. Am J Physiol 241:F175-F185
Safirstein R, Miller P, Guttenplan JR (1984) Uptake and metabolism of cisplatin by the kidney. Kidney Int 25:753–758
Safirstein R, Winston J, Moel D, Dikman S, Guttenplan J (1987) Cisplatin nephrotoxicity: insights into mechanism. Int J Androl 10:325–346
Schaeppi V, Heyman IA, Fleischman RW (1973)cis-Diamminedichloroplatinum(II) (NSC-119875): preclinical toxicological evaluation of intravenous injection in dogs, monkeys and mice. Toxicol Appl Pharmacol 25:230–241
Schilsky RL, Anderson T (1979) Hypomagnesemia and renal magnesium wasting in patients receivingcis-diamminedichloroplatinum(II). Ann Intern Med 90:929–931
Schilsky RL, Barlock A, Ozols RF (1980) Persistent hypomagnesemia following cisplatin chemotherapy for testicular cancer. Cancer Treat Rep 66:1767–1769
Schnermann I (1968) Micropuncture study of single short loops of Henle in rat kidney. Pflügers Arch 300:255–282
Shemesh O, Golbetz H, Kriss JP, Myers BD (1985) Limitations of creatinine as a filtration marker in glomerupathic patients. Kidney Int 28:830–838
Shils ME (1969) Experimental human magnesium depletion. Medicine 48:61–85
Slater JF, Almed M, Ibrahim SA (1977) Studies on the nephrotoxicity ofcis-dichlorodiammineplatinum and related substances. J Clin Hematol Oncol 7:534–544
Sørensen PG, Nissen MH, Groth S, Rørth M (1985) Beta-2-microglobulin excretion: an indicator of long term nephrotoxicity during cis-platinum treatment? Cancer Chemother Pharmacol 14:247–249
Stewart AF, Keating T, Schwartz RN, Schwartz PE (1985) Magnesium homeostasis following chemotherapy with cisplatin: a prospective study. Am J Obstet Gynecol 153:660–665
Thomsen K (1984) Lithium clearance: A new method for determining proximal and distal tubular reabsorption of sodium and water. Nephron 37:217–223
Uozumi J, Litterst CL (1985) The effect of cisplatin on renal ATPase activity in vivo and in vitro. Cancer Chemother Pharmacol 15:93–96
Uozumi J, Litterst CL (1986) The effect of sodium thiosulfate on subcellular localization of platinum in rat kidney after treatment with cisplatin. Cancer Lett 32:279–283
Uozumi J, Litterst L (1988) The effect of platinum levels in plasma, urine and kidney on blood urea nitrogen levels after cisplatin injection in rats. J Pharmacobiol Dyn 11:277–283
Uozumi J, Ishizawa M, Iwamoto Y, Baba T (1984) Sodium thiosulfate inhibitscis-diamminedichloroplatinum(II) activity. Cancer Chemother Pharmacol 13:82–85
Vogelzang NJ, Thorkelson JL, Kennedy BJ (1985) Hypomagnesemia, renal dysfunction and Raynaud's phenomenon in patients treated with cisplatin, vinblastine and bleomycin. Cancer 56:2765–2770
Ward JN, Fauvie KA (1976) The nephrotoxic effect ofcis-diamminedichloroplatinum(II) (NSC-119875) in male F 344 rats. Toxicol Appl Pharmacol 38:535–547
Winston JA, Safirstein R (1985) Reduced renal blood flow in early cisplatin-induced acute renal failure in the rat. Am J Physiol 249:F490-F496
Wong NLM, Quamme GA, Sutton RAL, Dirks JH (1979) Effect of mannitol on water and electrolyte transport in the dog kidney. J Clin Lab Med 94:563–592
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Daugaard, G., Abildgaard, U. Cisplatin nephrotoxicity. Cancer Chemother. Pharmacol. 25, 1–9 (1989). https://doi.org/10.1007/BF00694330
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DOI: https://doi.org/10.1007/BF00694330