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Statistical analysis of bioassays, based on hazard modelling

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Abstract

A stochastic model is proposed to describe time-dependent lethal effects of toxic compounds. It is based on simple mechanistic assumptions and provides a measure for the toxicity of a chemical compound, the so-called killing rate. The killing rate seems a promising alternative for the LC50. The model also provides the no-effect level and the LC50, both as a function of exposure time. The model is applied to real data and to simulated data.

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Authors and Affiliations

  1. Department of Theoretical Biology, Vrije Universiteit Amsterdam, De Boelelaan 1087, 1081, HV Amsterdam, The Netherlands

    J. J. M. Bedaux & S. A. L. M. Kooijman

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  1. J. J. M. Bedaux
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  2. S. A. L. M. Kooijman
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Bedaux, J.J.M., Kooijman, S.A.L.M. Statistical analysis of bioassays, based on hazard modelling. Environ Ecol Stat 1, 303–314 (1994). https://doi.org/10.1007/BF00469427

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  • DOI: https://doi.org/10.1007/BF00469427

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