Summary
Imipramine and its structural isomer propazepine were compared using 3 electrophysiological methods with these results:
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1.
EEG records in cortical and subcortical areas (hippocampus, thalamus) in rabbits with implanted electrodes after the administration of both drugs (5 mg/kg i.v.) did not differ. Imipramine had a greater antagonistic effect to cortical desynchronisation and subcortical synchronisation evoked by physostigmine (0,1 mg/kg i.V.).
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2.
The potentiation of thiopental anaesthesia measured by motor thresholds in rabbits with permanent epidural electrodes was greater after the administration of propazepine (2,5 mg/kg i.V.).
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3.
Imipramine (1 mg/kg, 1,5 mg/kg, 2 mg/kg i.p.) decreased the rate of self-stimulation in rats with electrodes implanted in ventrolateral hypothalamus, whilst propazepine in the dose of 1,5 mg/kg i.p. caused a significant increase in the rate of self-stimulation on the second day and in the dose of 2 mg/kg i.p. a significant decrease on the first day after the administration.
The results are discussed in respect to the clinical use.
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Benešová, O., Bohdanecký, Z. & Votava, Z. Electrophysiological comparison of the action of imipramine and propazepine. Psychopharmacologia 3, 423–431 (1962). https://doi.org/10.1007/BF00411159
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DOI: https://doi.org/10.1007/BF00411159