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Dentin as a possible bio-epidemiological measure of exposure to mercury

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Abstract

The subtle human health effects from prolonged exposure to small amounts of mercury vapor are unknown. It has been difficult to study possible effects of low-dose exposure for lack of a good measure of long-term exposure. Current methods which use blood, urine, hair, and nails reliably measure only recent exposures. Long-term exposure to lead has been measured using levels found in human dentin. The purpose of this study was to determine whether mercury also accumulates in dentin. In this study, dentin from 16 human teeth, all without dental amalgam restorations, was analyzed by thermal neutron activation analysis. The teeth were selected from people with and without dental mercury amalgam restorations elsewhere in their dentitions. Mercury was found in amounts up to 5.9 ppm. While the highest mercury level was from a sample from someone who had dental amalgam restorations elsewhere in their dentition, the second highest was from someone who had no amalgam restorations. Also, a sample which was not used for any statistical comparisons but which was analyzed because the tooth contained an amalgam restoration had one of the lowest levels of mercury. These results, while inconclusive due to a small sample size, suggest that inorganic mercury vapor is a relatively small contributor to the overall body burden of mercury.

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References

  • Amin-Zaki L, Elhassani S, Majeed MA, Clarkson TW, Doherty RA, Greenwood MR (1974) Studies of infants postnatally exposed to methylmercury. J Pediatr 85:81–84

    Google Scholar 

  • Amin-Zaki L, Majeed MA, Elhassani SB, Clarkson TW, Greenwood MR, Doherty RA (1979) Prenatal methylmercury poisoning clinical observations over five years. Am J Dis Child 133:172–177

    Google Scholar 

  • Bakir F, Damluji SF, Amin-Zaki L, Murtada M, Khalidi A, Al-Rawl NY, Tikriti S, Dhahir HI, Clarkson TW, Smith JC, Doherty RA (1973) Methylmercury poisoning in Iraq, an interuniversity report. Science 181:230–241

    Google Scholar 

  • Berglund A (1990) Estimation by a 24-hour study of the daily dose of intra-oral mercury vapor inhaled after release from dental amalgam. J Dent Res 69:1646–1651

    Google Scholar 

  • Berglund A, Pohl L, Olsson S, Bergman M (1988) Determination of the rate of release of intra-oral mercury vapor from amalgam. J Dent Res 67:1235–1242

    Google Scholar 

  • Clarkson TW, Weiss B, Cox C (1983) Public health consequences of heavy metal dump sites. Environ Health Perspec 48:113–127

    Google Scholar 

  • Cox C, Clarkson TW, Marsh DO, Amin-Zaki L, Tikriti S, Myers GG (1989) Dose-response analysis of infants prenatally exposed to methyl mercury: an application of a single compartment model to single-strand hair analysis. Environ Res 49:318–332

    Google Scholar 

  • Eide R, Wesenbert GR, Fosse G (1992) Mercury in Primary Teeth in preindustrial Norway, abstract #69 presented at the Scandinavian Association for Dental Research 74th Annual Meeting August 22–24, 1991, Helsinki, Finland

  • Fawer RF, De Ribaupierre Y, Guillemin MP, Berode M, Lob M (1983) Measurement of hand tremor induced by industrial exposure to metallic mercury. Br J Ind Med 40:204–208

    Google Scholar 

  • Frank RM, Sargentini-Maier ML, Leroy MJ, Turlot JC (1988) Agerelated lead increase in human permanent teeth demonstrated by energy dispersive x-ray fluorescence. J Trace Elem Electrolytes Health Dis 2:175–179

    Google Scholar 

  • Haavikko K, Anttila A, Helle A, Vuori E (1984) Lead concentrations of enamel and dentine of deciduous teeth of children from two Finnish towns. Arch Environ Health 39:78–84

    Google Scholar 

  • Iyengar GV, Kollmer WE, Bowen HJM (1978) In: Ebel HF, Weinheim FDR (eds) Elemental composition of human tissues and body fluids. Verlag Chemie

  • Kanabrocki EL, Kanabrocki JA, Greco J, Kaplan E, Oester YT (1979) Instrumental analysis of trace elements in thumbnails of human subjects. Sci Tot Environ 13:131–140

    Google Scholar 

  • Kazantzis G, Al-Mufti AW, Al-Jawad A, Al-Shahwani Y, Majid MA, Mahmoud RM, Soufi M, Tawfiq K, Ibrahim MA, Dabagh H (1976) Epidemiology of organomercury poisoning in Iraq. II. Relationship of mercury levels in blood and hair to exposure and to clinical findings. Bull WHO (Suppl) 53:37–48

    Google Scholar 

  • Little MF, Steadman LT (1966) Chemical and physical properties of altered and sound enamel. Arch Oral Biol 11:273–278

    Google Scholar 

  • Logan W, Kronfeld R (1933) J Am Dent Assoc 20:379 as found in: (1984) Ash MM (ed) Wheeler's dental anatomy, physiology, and occlusion, 6th ed. WB Saunders Co

  • Lundberg M, Soremark R, Thilander H (1965a) The concentration of some elements in the enamel of unerupted (impacted) human teeth. Odont Revy 16:8–11

    Google Scholar 

  • —, —, — (1965b) The concentration of some elements in the dentine of unerupted (impacted) human teeth. Odont Revy 16:97–100

    Google Scholar 

  • Mackert JR (1987) Factors affecting estimation of dental amalgam mercury exposure from measurements of mercury vapor levels in intra-oral expired air. J Dent Res 66:1775–1780

    Google Scholar 

  • Marsh DO, Clarkson TW, Cox C, Myers GJ, Amin-Zaki L, Al-Tikriti S (1987) Fetal methylmercury poisoning. Relationship between concentration in single strands of maternal hair and child effects. Arch Neurol 44:1017–1022

    Google Scholar 

  • Miller JM, Chaffin DB, Smith RG (1975) Subclinical psychomotor and neuromuscular changes in workers exposed to inorganic mercury. Am Ind Hyg Assoc 725–733

  • Moller B, Carlsson L, Johansson GI, Malmqvist KG, Hammarstrom L, Berlin M (1982) Lead levels determined in Swedish permanent teeth by particle-induced x-ray emission. Scand J Work Environ Health 8:267–272

    Google Scholar 

  • Needleman HL, Gunnoe C, Leviton A, Reed R, Peresie H, Maher C, Barrett P (1979) Deficits in psychologic and classroom performance of children with elevated dentine lead levels. N Engl J Med 300:689–695

    Google Scholar 

  • Nixon GS, Paxton GD, Smith H (1965) Estimation of mercury in human enamel by activation analysis. J Dent Res 44:654–656

    Google Scholar 

  • Olsson S, Berglund A, Pohl L, Bergman (1989) Model of mercury vapor transport from amalgam restorations in the oral cavity. J Dent Res 68:504–508

    Google Scholar 

  • Patterson LJ, Raab GM, Hunter R, Laxen DP, Fulton J, Fell GS, Halls DJ, Sutcliffe P (1988) Factors influencing lead concentrations in shed deciduous teeth. Sci Total Environ 74:219–233

    Google Scholar 

  • Phelps RW, Clarkson TW, Kershaw TG, Wheatley B (1980) Interrelationships of blood and hair mercury concentrations in a North American population exposed to methylmercury. Arch Environ Health 35(3):161–168

    Google Scholar 

  • Piikivi L, Hanninen J, Martelin T, Pirjo M (1984) Psychological performance and long-term exposure to mercury vapors. Scand J Environ Health 10:35–41

    Google Scholar 

  • Rabinowitz MB, Leviton A, Bellinger D (1989) Blood lead-tooth lead relationship among Boston children. Bull Environ Contam Toxicol 43:485–492

    Google Scholar 

  • Rasmussen EG (1974) Antimony, arsenic, bromine and mercury in enamel from human teeth. Scand J Dent Res 82:562–565

    Google Scholar 

  • Retief DH, Cleaton-Jones PE (1971) The quantitative analysis of sixteen elements in normal human enamel and dentine by neutron activation analysis and high-resolution gamma-spectrometry. Arch Oral Biol 16:1257–1267

    Google Scholar 

  • Smith J, Langolf GD, Goldberg J (1982) Effects of occupational exposure to elemental mercury on short term memory. Br J Ind Med 40:413–419

    Google Scholar 

  • Snapp KR, Boyer DB, Peterson LC, Svare CW (1989) The contribution of dental amalgam to mercury in blood. J Dent Res 68:780–785

    Google Scholar 

  • Soremark R, Samsahl K (1962) Gamma-ray spectrometric analysis of elements in normal human dentine. J Dent Res 41:603–606

    Google Scholar 

  • Svare CW, Peterson LC, Reinhardt, JW Boyer DB, Frank CW, Gay DD, Cox RD (1981) The effect of dental amalgams on mercury levels in expired air. J Dent Res 60:1668–1671

    Google Scholar 

  • Tate WH, White RR (1991) Disinfection of human teeth for educational purposes. J Dent Educ 55(9) 583–585

    Google Scholar 

  • Tsubaki T, Krukuyama K (1977) Minimata disease. Elsevier Scientific Publishing Co, Amsterdam

    Google Scholar 

  • Verberk MM, Salle HJ, Kemper CH (1986) Tremor in workers with low exposure to metallic mercury. Am Ind Hyg Assoc J 47(8):559–562

    Google Scholar 

  • Vimy MJ, Lorscheider FL (1985) Intra-oral air mercury released from dental amalgam J Dent Res 64:1069–1071

    Google Scholar 

  • Vimy MJ, Luft AJ, Lorscheider FL (1986) Estimation of mercury body burden from dental amalgam: computer simulation of a metabolic compartmental model. J Dent Res 65:1415–1419

    Google Scholar 

  • Young AG, Taylor FHL, Merritt HH (1930) The distribution and excretion of mercury. Arch Dermatol Syphalology 21:539–551

    Google Scholar 

  • Ziff S (1984) The toxic time bomb. Aurora Press, NY, pp 80–81

    Google Scholar 

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Haller, L.A., Olmez, I., Baratz, R. et al. Dentin as a possible bio-epidemiological measure of exposure to mercury. Arch. Environ. Contam. Toxicol. 25, 124–128 (1993). https://doi.org/10.1007/BF00230722

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  • DOI: https://doi.org/10.1007/BF00230722

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