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Assignment of the developmentally regulated gene NEDD1 to human chromosome 12q22 by fluorescence in situ hybridization

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Abstract

The developmentally regulated mouse gene Nedd 1 encodes a protein showing similarities with the β-subunit of heterotrimeric GTP-binding proteins and has growth suppressing activity when overexpressed in various cultured cell types. We have mapped the human homolog (NEDD1) of the mouse gene to chromosome 12q22 by fluorescence in situ hybridization using R-banded human (pro)metaphase chromosomes.

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References

  • Bonnet D, Pelet A, Legeai-Mallet L, Sidi D, Mathieu M, Parent P, Plauchu H, Serville F, Schinzel A, Weissenbach J, Kachaner J, Munnich A, Lyonnet S (1994) A gene for Holt-Oram syndrome maps to the distal long arm of chromosome 12. Nature Genet 6:405–408

    Google Scholar 

  • Kumar S, Tomooka Y, Noda M (1992) Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun 185:1155–1161

    Google Scholar 

  • Kumar S, Matsuzaki T, Yoshida Y, Noda M (1994) Molecular cloning and biological activity of a novel developmentally regulated gene encoding a protein with β-transducin-like structure. J Biol Chem 269:11318–11326

    Google Scholar 

  • Lawrence JB, Villnave CA, Singer RH (1988) Sensitive, high resolution chromatin and chromosome mapping in situ: presence and orientation of two closely integrated copies of EBV in a lymphoma cell line. Cell 52:51–61

    Google Scholar 

  • Mitelman F, Kaneko Y, Trent J (1991) Report of the committee on chromosome changes in neoplasia. Cytogenet Cell Genet 58:1053–1079

    Google Scholar 

  • Pinkel D, Strauma T, Gray JW (1986) Cytogenetic analysis using quantitative, high sensitivity, fluorescence hybridization. Proc Natl Acad Sci USA 83:2934–2938

    Google Scholar 

  • Samaniego F, Rodriguez E, Houldsworth J, Murty VVVS, Ladanyi M, Lele KP, Chen Q, Dmitrovsky E, Geller NL, Reuter V, Jhanwar SC, Bosl GJ, Chaganti RS K (1990) Cytogenetic and molecular analysis of human male germ cell tumors: chromosome 12 abnormalities and gene amplification. Genes Chromosom Chancer l:289–300

    Google Scholar 

  • Takahashi E, Hori T, O'Connell P, Leppert M, White R (1990) R-banding and nonisotopic in situ hybridization: precise localization of the human type II collagen gene (COL2A1). Hum Genet 86:14–16

    Google Scholar 

  • Takahashi E, Hori T, O'Connell P, Leppert M, White R (1991) Mapping of the MYC gene to band 8q24. 12-q24. 13 by R-banding and distal to fra(8)(q24. 11), FRA8E, by fluorescence in situ hybridization. Cytogenet Cell Genet 57:109–111

    Google Scholar 

  • Takai S, Nishino N, Kitayama H, Ikawa Y, Noda M (1993) Mapping of the KREV1 transformation suppressor gene and its pseudogene (KREV1P) to human chromosome 1p13. 3 and 14q24. 3, respectively, by fluorescence in situ hybridization. Cytogenet Cell Genet 63:59–61

    Google Scholar 

  • Takai S, Kasama K, Yamada K, Kai N, Hirayama N, Namiki H, Taniyama T (1994a) Human high-affinity FcgRI (CD64) gene mapped to chromosome 1q21. 1-q21. 3 by fluorescence in situ hybridization. Hum Genet 93:13–15

    Google Scholar 

  • Takai S, Yamada K, Hirayama N, Miyajima A, Taniyama T (1994b) Mapping of the human gene encoding the mutual signaltransducing subunit (β-chain) of the human granulocytemacrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and interleukin-5 (IL-5) receptor complexes to chromosome 22q13. 1. Hum Genet 93:198–200

    Google Scholar 

  • Terrett JA, Newbury-Ecob R, Cross GS, Fenton I, Raeburn A, Young ID, Brook JD (1994) Holt-Oram syndrome is a genetically heterogeneous disease with one locus mapping to human chromosome 12q. Nature Genet 6:401–404

    Google Scholar 

  • Viegas-Pequignot E, Dutrillaux B (1978) Une methode simple pour obtenir des prophases et des prometaphases. Ann Genet (Paris) 21:122–125

    Google Scholar 

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Takai, S., Yoshida, Y., Noda, M. et al. Assignment of the developmentally regulated gene NEDD1 to human chromosome 12q22 by fluorescence in situ hybridization. Hum Genet 95, 96–98 (1995). https://doi.org/10.1007/BF00225082

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  • DOI: https://doi.org/10.1007/BF00225082

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