Abstract
A patient was treated with low-dose methotrexate because of psoriasis that did not respond to conventional therapy. During treatment, visual symptoms occurred; optic disc swelling was found, and later slight optic disc atrophy. Moreover, paracentral relative visual field defects showed fluctuations parallel to methotrexate dose changes. It seems likely that methotrexate affected optic nerve function.
Similar content being viewed by others
References
Henriksson R, Bergström P, Grankvist K, Johansson Ö. Interactions between cytotoxic drugs and other pharmaceuticals. Nordisk Medicin 1990; 105: 335–7.
Grant WM. Toxicology of the Eye, 3d ed. Charles C. Thomas, 1986.
Duke-Elder S. System of Ophthalmology, Vol. 12. London: Henry Kimpton, 1971: 91ff.
Duke-Elder S. System of Ophthalmology, Vol. 14. London: Henry Kimpton, 1971: 133–4.
Rook A, Wilkinson DS, Ebling FJG, Champion RH, Burton JL. Textbook of Dermatology, 4th ed. Balckwell Scientific Publications, 1986: 1500–3.
Farmakologiska Specialiteter i Sverige. Stockholm (Sweden): Läkemedelsinformation AB, 1990.
Lischka G. Auffallend rasche Wirkung des Methotrexats bei Psoriasis eines 82jährigen Patienten mit gleichzeitigen Nebenwirkungen am Auge. Hautarzt 1968; 19(10): 473.
Gruber GG, Callen JP. Systemic complications of commonly used dermatologic drugs. Cutis 1978; 21(6): 825–9.
Doroshow JH, Locker GY, Gasterland DE, Hubbard SP, Young RC, Myers CE, Ocular irritation from high-dose methotrexate therapy: pharmacokinetics of drug in the tear film. Cancer 1981: 48: 2158–62.
Imperia PS, Lazarus HM, Lass JH. Ocular complications of systemic cancer chemotherapy. Survey of Ophthalmology 1989; 34(3): 209–230.
Dunbar Hoskins H, Magee SD, Drake MV, Kidd MN. Confidence intervals for change in automated visual field, Br J Ophthalmol 1988; 72: 591–7.
Sörensen TT, Sörensen PS. Oftalmoplegi efter lavdosis methotrexat. Ugeskrift for laeger 1988; 19: 150(51): 2197–8.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Johansson, B.A. Visual field defects during low-dose methotrexate therapy. Doc Ophthalmol 79, 91–94 (1992). https://doi.org/10.1007/BF00160135
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00160135