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Liver Growth and Repair pp 219–239Cite as

Hepatocyte growth factor in liver growth and differentiation

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Abstract

HGF was originally isolated from platelets and serum from hepatectomized rats in several laboratories during the early 1980s (Strain, McGowan and Bucher, 1982; Michalopoulos et al., 1983; Russell, McGowan and Bucher, 1984; Nakamura, Nawa and Ichihara, 1984). It was identified as hepatopoietin A in 1983 (Michalopoulos et al., 1983), was eventually purified to homogeneity and subsequently cloned and sequenced in 1989, and named hepatocyte growth factor (HGF) (Miyazawa et al., 1989; Nakamura et al., 1989). Studies on factors related to cell motility also identified a protein called scatter factor (Stoker et al., 1987). Subsequent purification and cloning of scatter factor demonstrated that it was identical to HGF (Gherardi and Stoker, 1990). Similarly, research by Higashio et al. (1990) identified a substance that was mito-inhibitory to sarcoma cells. This substance, known as tumor cytotoxic factor (Higashio et al., 1990), was also subsequently identified as identical to HGF. This triple line of the discovery and characterization of HGF underlines much of the knowledge that has been accumulated since the original cloning and sequencing of the growth factor. More than 500 publications since 1989 have demonstrated the multiplicity of the effects of HGF on many tissues, and have highlighted a very complex biology that transcends from matrix to motility, from morphogenesis to embryogenesis, and also from neoplastic growth to tissue regeneration.

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  1. Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

    George Michalopoulos

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Alastair Strain Anne Mae Diehl

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Michalopoulos, G. (1998). Hepatocyte growth factor in liver growth and differentiation. In: Strain, A., Diehl, A.M. (eds) Liver Growth and Repair. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4932-7_8

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  • DOI: https://doi.org/10.1007/978-94-011-4932-7_8

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