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The Mitomycin Antibiotics

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Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products

Abstract

The mitomycins were first obtained in 1956 from Streptomyces caespitosus by Hata and coworkers in Japan (1, 2). The isolation involved alumina chromatography of the chloroform extracts of the concentrated aqueous filtrates of the fermentation broth. Although there were many active components in the eluted fractions, only two antibiotics, mitomycins A and B were obtained in crystalline form. Later fractionations of broths of S. caespitosus yielded mitomycin C (3). By 1958, the outstanding antitumor activity of mitomycin C was a subject of great interest in spite of the fact that there existed no firm evidence as to its structure (4). In 1960, N-methylmitomycin C, called porfiromycin, was isolated from cultures of Streptoverticillatium ardus (5). In 1962 the isolation of the same four antibiotics from Streptomyces verticillatus was reported in the U.S. (6). Additionally, a fifth, but inactive member of mitomycin family, mitiromycin was obtained. The fractionation of the S. verticillatus broths to afford the crystalline antibiotics was accomplished by partition chromatography on a diatomaceous earth support.

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  1. Department of Chemistry, Fordham University, Bronx, N.Y., USA

    R. W. Franck

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Editors and Affiliations

  1. Department of Chemistry, The Florida State University, Tallahassee, Florida, USA

    W. Herz (Professor of Chemistry) (Professor of Chemistry)

  2. Biologisches Institut II, Lehrstuhl für Biochemie der Pflanzen, Albert-Ludwigs-Universität, Freiburg i. Br., Federal Republic of Germany

    H. Grisebach

  3. Chemistry Department, The University, Glasgow, Scotland

    G. W. Kirby Sc. D. (Regius Professor of Chemistry) (Regius Professor of Chemistry)

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Franck, R.W. (1979). The Mitomycin Antibiotics. In: Herz, W., Grisebach, H., Kirby, G.W. (eds) Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products. Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products, vol 38. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8548-3_1

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