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Hepadnaviruses pp 103–140Cite as

Cellular and Molecular Mechanisms of Hepatocarcinogenesis Associated with Hepadnavirus Infection

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 168))

Abstract

A large number of inorganic and organic chemicals act as carcinogens in the liver. Most of these are not active until they are metabolized into short-lived electrophilic forms by the mixed function oxidase systems, e.g., P450 and P448, which is most abundant in the liver. The process of carcinogenesis is initiated when an electrophilic form binds to cellular macromolecules, most importantly DNA, and causes a permanent alteration in the nucleotide sequence. Some of the cells that have been altered in this manner are said to be “initiated”, meaning that they have acquired characteristics which may be expressed in cancer cells (Scherer 1989; Farber 1973; Sell et al. 1987).

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Authors and Affiliations

  1. Liver Research Center, Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10401, Bronx, NY, USA

    C. E. Rogler

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  1. C. E. Rogler
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  1. Fox Chase Cancer Center, 7701 Burholme Ave., Philadelphia, PA, 19111, USA

    William S. Mason  & Christoph Seeger  & 

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Rogler, C.E. (1991). Cellular and Molecular Mechanisms of Hepatocarcinogenesis Associated with Hepadnavirus Infection. In: Mason, W.S., Seeger, C. (eds) Hepadnaviruses. Current Topics in Microbiology and Immunology, vol 168. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76015-0_6

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  • DOI: https://doi.org/10.1007/978-3-642-76015-0_6

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