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Historical Introduction and Chemical Characteristics of Antituberculosis Drugs

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Antituberculosis Drugs

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 84))

Abstract

In 1940 Bernheim observed that virulent Mycobacterium tuberculosis cultures are stimulated in their respiration under the influence of small quantities of benzoic and salicylic acids without these acids themselves being oxidized. Subsequently Lehmann (1946a, b) established that this stimulation is reversed at higher concentrations of salicylic acid. He therefore looked among the many salicylic acid derivatives for antimetabolites that, like the pair sulphanilamide-p-aminobenzoic acid, would be capable of competitively displacing salicylic acid from the reaction site. In 2-hydroxy-4-aminobenzoic acid, as described by Seidel in 1901 and by Seidel and Bittner in 1902, Lehmann found a substance (PAS) that fulfilled his expectations and called it β m-aminosalicylic acid. He also found that other hydroxyaminobenzoic acids did not have this inhibitory effect, and that the substance acts specifically only against Mycobacterium tuberculosis strains. Lehmann described not his fundamental microbiological metabolic experiments but also the animal-experimental and clinical studies he performed with PAS.

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  1. H. A. Offe
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  1. Julius-Lucas-Weg 67, D-5600, Wuppertal 1, Germany

    Karl Bartmann

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Offe, H.A. (1988). Historical Introduction and Chemical Characteristics of Antituberculosis Drugs. In: Bartmann, K. (eds) Antituberculosis Drugs. Handbook of Experimental Pharmacology, vol 84. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72873-0_1

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