Abstract
Segmentations of brain lesions from Magnetic Resonance (MR) images is crucial for quantitative analysis of lesion populations in neuroimaging of neurological disorders. We propose a new method for segmenting lesions in brain MRI by inferring the underlying physical models for pathology. We use the reaction-diffusion model as our physical model, where the diffusion process is guided by real diffusion tensor fields that are obtained from Diffusion Tensor Imaging (DTI). The method performs segmentation by solving the inverse problem, where it determines the optimal parameters for the physical model that generates the observed image. We show that the proposed method can infer reasonable models for multiple sclerosis (MS) lesions and healthy MRI data. The method has potential for further extensions with different physical models or even non-physical models based on existing segmentation schemes.
This work is part of the National Alliance for Medical Image Computing (NA-MIC), funded by the National Institutes of Health through Grant U54 EB005149. Information on the National Centers for Biomedical Computing can be obtained from http://www.nihroadmap.nih.gov /bioinformatics
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Bakshi, R., Caruthersa, S.D., Janardhana, V., Wasay, M.: Intraventricular csf pulsation artifact on fast fluid-attenuated inversion-recovery MR images: Analysis of 100 consecutive normal studies. AJNR 21, 503–508 (2000)
Zijdenbos, A., Forghani, R., Evans, A.: Automatic quantification of MS lesions in 3D MRI brain data sets: Validation of INSECT. In: Wells, W.M., Colchester, A.C.F., Delp, S.L. (eds.) MICCAI 1998. LNCS, vol. 1496, pp. 439–448. Springer, Heidelberg (1998)
Thirion, J.P., Calmon, G.: Deformation analysis to detect and quantify active lesions in three-dimensional medical image sequences. IEEE TMI 18, 429–441 (1999)
Rey, D., Subsol, G., Delingette, H., Ayache, N.: Automatic detection and segmentation of evolving processes in 3D medical images: Application to multiple sclerosis. Medical Image Analysis 6, 163–179 (2002)
van Leemput, K., Maes, F., Vandermeulen, D., Colchester, A., Suetens, P.: Automated segmentation of multiple sclerosis lesions by model outlier detection. IEEE TMI 20, 677–688 (2001)
Mohamed, A., Zacharaki, E.I., Shen, D., Davatzikos, C.: Deformable registration of brain tumor images via a statistical model of tumor-induced deformation. MedI.A 10 (2006)
Clatz, O., Sermesant, M., Bondiau, P.Y., Delingette, H., Warfield, S.K., Malandain, G., Ayache, N.: Realistic simulation of the 3d growth of brain tumors in mr images including diffusion and mass effect. IEEE Transactions on Medical Imaging 24, 1344–1346 (2005)
Cocosco, C.A., Kollokian, V., Kwan, R.S., Evans, A.C.: BrainWeb: Online interface to a 3D MRI simulated brain database. Neuroimage 5 (1997)
Goodlett, C., Davis, B., Jean, R., Gilmore, J., Gerig, G.: Improved correspondence for dti population studies via unbiased atlas building. In: Larsen, R., Nielsen, M., Sporring, J. (eds.) MICCAI 2006. LNCS, vol. 4191, pp. 260–267. Springer, Heidelberg (2006)
Maes, F., Collignon, A., Vandermeulen, D., Marchal, G., Suetens, P.: Multimodality image registration by maximization of mutual information. IEEE Trans. Med. Imaging 16, 187–198 (1997)
Hughes, T.J.R.: The finite element method: linear static and dynamic finite element analysis. Dover (2000)
Lee, H.C., Cok, D.R.: Detecting boundaries in a vector field. IEEE Trans. Signal Processing 39, 1181–1194 (1991)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2008 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Prastawa, M., Gerig, G. (2008). Brain Lesion Segmentation through Physical Model Estimation. In: Bebis, G., et al. Advances in Visual Computing. ISVC 2008. Lecture Notes in Computer Science, vol 5358. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-89639-5_54
Download citation
DOI: https://doi.org/10.1007/978-3-540-89639-5_54
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-89638-8
Online ISBN: 978-3-540-89639-5
eBook Packages: Computer ScienceComputer Science (R0)