Heparin-Conjugated Nanointerfaces for Biomedical Applications

Park, Ki Dong; Joung, Yoon Ki; Bae, Jin Woo; Go, Dong Hyun

doi:10.1007/978-3-540-49661-8_10

Ki Dong Park⁴,
Yoon Ki Joung⁴,
Jin Woo Bae⁴ &
…
Dong Hyun Go⁴

1539 Accesses

Abstract

This chapter describes some examples of heparin-conjugated nanointerfaces for biomedical applications in terms of both development and application. First, heparin-conjugated linear and star shaped poly(lactic acid) (PLA-Hep and sPLA-Hep) to improve blood compatibility and its related biocompatibility of degradable polymers were introduced. Second, a heparin-conjugated PM system that consists of Tetronic and poly(ɛ-caprolactone) (PCL) is described as an injectable vehicle for an effective long-term delivery of growth factors. Finally, the heparin-immobilized small intestinal submucosa (SIS) was investigated to observe the effect of heparin immobilization on blood compatibility, in vitro fibroblast attachment and in vivo calcification of SIS. All of these examples demonstrate that heparin-conjugated nanointerfaces might be a versatile and promising tool to achieve advanced biomaterials.

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Authors and Affiliations

Dept. of Molecular Science and Technology, Ajou University, SUWON, 443-749, Korea
Ki Dong Park, Yoon Ki Joung, Jin Woo Bae & Dong Hyun Go

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Ki Dong Park
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Yoon Ki Joung
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Jin Woo Bae
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Dong Hyun Go
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Correspondence to Ki Dong Park .

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Department of Chemical and Materials Engineering, College of Engineering, University of Cincinnati, Cincinnati, OH, 45221, USA
Donglu Shi
The Institute for Advanced Materials and Nano Biomedicine, Tongji University, Shanghai, 200092, China
Donglu Shi
Research Institute of Micro/Nano Science and Technology, Shanghai Jiao Tong University, Shanghai, 200240, China
Donglu Shi

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Park, K.D., Joung, Y.K., Bae, J.W., Go, D.H. (2009). Heparin-Conjugated Nanointerfaces for Biomedical Applications. In: Shi, D. (eds) NanoScience in Biomedicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-49661-8_10

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DOI: https://doi.org/10.1007/978-3-540-49661-8_10
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-49660-1
Online ISBN: 978-3-540-49661-8
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