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Titania Nanotubes for Local Drug Delivery from Implant Surfaces

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Electrochemically Engineered Nanoporous Materials

Part of the book series: Springer Series in Materials Science ((SSMATERIALS,volume 220))

Abstract

The principal challenge for bone therapy is to deliver an effective dose of therapeutic agent (for example antibiotic or anti-cancer drug) to the affected site within bone, while sparing other organs. The solution to this dilemma is to deliver drug locally within the bone; hence various surface/therapeutic modifications of the conventional bone implants have been suggested to achieve this. Implants composed of biocompatible materials and loaded with active therapeutics thus provide one possible option for effective bone therapy. This chapter showcases the challenges that an electrochemically nano-engineered bone implant based on titania nanotubes must overcome to survive and deliver therapeutics in conditions such as infections and cancer of bone. The fabrication of titania nanotubes, the therapeutic loading and release, ex vivo and in vivo investigations; all are reviewed in terms of effectiveness for therapeutic action. Also discussed are the potential advances of titania nanotube technology and the future research directions to address additional clinical problems.

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Acknowledgments

The authors acknowledge the financial support of ARC DP 120101680, FT 110100711, and The University of Adelaide. SM was supported in part by a pre-doctoral fellowship from the Egyptian Ministry of Higher Education.

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Authors and Affiliations

  1. School of Chemical Engineering, University of Adelaide, Adelaide, Australia

    Karan Gulati, Shaheer Maher & Dusan Losic

  2. Discipline of Orthopaedics & Trauma, University of Adelaide, Adelaide, Australia

    Masakazu Kogawa, Gerald Atkins & David Findlay

  3. Faculty of Pharmacy, Assiut University, Assiut, Egypt

    Shaheer Maher

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  1. Karan Gulati
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  2. Masakazu Kogawa
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Correspondence to Dusan Losic .

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  1. School of Chemical Engineering, The University of Adelaide, Adelaide, Australia

    Dusan Losic

  2. School of Chemical Engineering, The University of Adelaide, Adelaide, Australia

    Abel Santos

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Gulati, K., Kogawa, M., Maher, S., Atkins, G., Findlay, D., Losic, D. (2015). Titania Nanotubes for Local Drug Delivery from Implant Surfaces. In: Losic, D., Santos, A. (eds) Electrochemically Engineered Nanoporous Materials. Springer Series in Materials Science, vol 220. Springer, Cham. https://doi.org/10.1007/978-3-319-20346-1_10

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