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From Cell Activation to Cell Depletion

The Programmed Cell Death Hypothesis of AIDS Pathogenesis

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Book cover Cell Activation and Apoptosis in HIV Infection

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 374))

Abstract

Acquired immunodeficiency syndrom (AIDS) provides a spectacular illustration of the capacity of a pathogen, the human immunodeficiency virus (HIV), to induce in about ten years a progressive and complete loss of immune competence in the infected host by causing the loss of the lymphocyte population that plays a central role in the control of the immune response, the CD4+ T helper cells1,2.

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  1. INSERM U 415 Pathogenèse du sida et des infections à tropisme immunitaire et nerveux, Institut Pasteur, 1 rue du Pr. A. Calmette, Lille, 59019, France

    Jean Claude Ameisen

  2. Faculté de Médecine, Université Lille II, Lille, France

    Jean Claude Ameisen

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  1. Laennec Hospital, Paris, France

    Jean-Marie Andrieu  & Wei Lu  & 

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Ameisen, J.C. (1995). From Cell Activation to Cell Depletion. In: Andrieu, JM., Lu, W. (eds) Cell Activation and Apoptosis in HIV Infection. Advances in Experimental Medicine and Biology, vol 374. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1995-9_13

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