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Profiling Epigenetic Alterations in Disease

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Book cover Epigenetic Contributions in Autoimmune Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 711))

Abstract

Nowadays, epigenetics is one of the fastest growing research areas in biomedicine. Studies have demonstrated that changes in the epigenome are not only common in cancer, but are also involved in the pathogenesis of noncancerous diseases like immunological, cardiovascular, developmental and neurological/psychiatric disorders. At the same time, during the last years, a technological revolution has taken place in the field of epigenomics, which is defined as the study of epigenetic changes throughout the whole genome. Microarray technologies and more recently, the development of next generation sequencing devices are now providing researchers with tools to draw high-resolution maps of DNA methylation and histone modifications in normal tissues and diseases. This chapter will review the currently available high-throughput techniques for studying the epigenome and their applications for characterizing human diseases.

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  1. Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain

    José Ignacio Martín-Subero & Manel Esteller

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  1. José Ignacio Martín-Subero
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  1. Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain

    Esteban Ballestar PhD

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Martín-Subero, J.I., Esteller, M. (2011). Profiling Epigenetic Alterations in Disease. In: Ballestar, E. (eds) Epigenetic Contributions in Autoimmune Disease. Advances in Experimental Medicine and Biology, vol 711. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8216-2_12

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