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Molecular Mechanisms of Parasite Invasion pp 174–181Cite as

Leishmania Invasion and Phagosome Biogenesis

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Part of the book series: Subcellular Biochemistry ((SCBI,volume 47))

Abstract

Whereas bacterial pathogens take over the control of their host cell actin cytoskeleton by delivering an array of protein effectors through specialized secretion systems, promastigotes of the protozoan parasite Leishmania donovani rely entirely upon a cell surface glycolipid to achieve this feat. Here, we review recent evidence that L. donovani promastigotes subvert host macrophage actin dynamics during the establishment of infection and we discuss the potential mechanisms involved.

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Author information

Authors and Affiliations

  1. INRS-Institut Armand-Frappier, 531, boul. des Prairies, Laval, Quebec, H7V 1 B7, Canada

    Robert Lodge & Albert Descoteaux

Authors
  1. Robert Lodge
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  2. Albert Descoteaux
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Correspondence to Albert Descoteaux .

Editor information

Editors and Affiliations

  1. Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA

    Barbara A. Burleigh PhD

  2. Department of Biological Sciences, Imperial College, London, UK

    Dominique Soldati-Favre PhD

  3. Département de Microbiologie et Medecine Moléculaire, Université de Genève, Geneve, Switzerland

    Dominique Soldati-Favre PhD

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© 2008 Landes Bioscience and Springer Science+Business Media

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Lodge, R., Descoteaux, A. (2008). Leishmania Invasion and Phagosome Biogenesis. In: Burleigh, B.A., Soldati-Favre, D. (eds) Molecular Mechanisms of Parasite Invasion. Subcellular Biochemistry, vol 47. Springer, New York, NY. https://doi.org/10.1007/978-0-387-78267-6_14

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