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hnRNP Proteins and Splicing Control

  • Chapter
Alternative Splicing in the Postgenomic Era

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 623))

Abstract

Proteins of the heterogeneous nuclear ribonucleoparticles (hnRNP) family form a structurally diverse group of RNA binding proteins implicated in various functions in metazoans. Here we discuss recent advances supporting a role for these proteins in precursor-messenger RNA (pre-mRNA) splicing. Heterogeneous nuclear RNP proteins can repress splicing by directly antagonizing the recognition of splice sites, or can interfere with the binding of proteins bound to enhancers. Recently, hnRNP proteins have been shown to hinder communication between factors bound to different splice sites. Conversely, several reports have described a positive role for some hnRNP proteins in pre-mRNA splicing. Moreover, cooperative interactions between bound hnRNP proteins may encourage splicing between specific pairs of splice sites while simultaneously hampering other combinations. Thus, hnRNP proteins utilize a variety of strategies to control splice site selection in a manner that is important for both alternative and constitutive pre-mRNA splicing.

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  1. Département de Microbiologie et d’Infectiologie, Université de Sherbrooke, Sherbrooke, Québec, Canada

    Rebeca Martinez-Contreras, Philippe Cloutier, Lulzim Shkreta, Jean-François Fisette, Timothée Revil & Benoit Chabot

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  1. Rebeca Martinez-Contreras
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  2. Philippe Cloutier
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  3. Lulzim Shkreta
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  4. Jean-François Fisette
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  6. Benoit Chabot
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Correspondence to Benoit Chabot .

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  1. Banting and Best Department of Medical Research and Department of Molecular and Medical Genetics, Terrence Donnelly Center for Cellular and Biomedical Research, University of Toronto, Toronto, Canada

    Benjamin J. Blencowe Ph.D.

  2. Department of Genetics and Development Biology, University of Connecticut Health Center, Farmington, Connecticut, USA

    Brenton R. Graveley Ph.D.

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Martinez-Contreras, R., Cloutier, P., Shkreta, L., Fisette, JF., Revil, T., Chabot, B. (2007). hnRNP Proteins and Splicing Control. In: Blencowe, B.J., Graveley, B.R. (eds) Alternative Splicing in the Postgenomic Era. Advances in Experimental Medicine and Biology, vol 623. Springer, New York, NY. https://doi.org/10.1007/978-0-387-77374-2_8

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