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NMR Spectroscopy in Fragment Based Drug Design

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Lead-Seeking Approaches

Part of the book series: Topics in Medicinal Chemistry ((TMC,volume 5))

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Abstract

In this chapter we will briefly reiterate critical aspects of solution nuclear magnetic resonance (NMR) spectroscopy approaches and their applications in drug discovery. These approaches are essentially based on a number of NMR techniques that have been developed to monitor and characterize intermolecular interactions. By way of examples, we will illustrate the unique advantages that these techniques offer when employed in conjunction with fragment-based ligand design, especially when tackling challenging drug targets.

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Acknowledgments

Several review articles cover in much greater details numerous NMR applications that have been reported in the past years on the use of NMR spectroscopy in the drug discovery process and to monitor target-ligand interactions. The author apologizes if he was unable to mention properly all this work within the limited space of this article.

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Authors and Affiliations

  1. Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Maurizio Pellecchia

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  1. Maurizio Pellecchia
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Correspondence to Maurizio Pellecchia .

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Editors and Affiliations

  1. Dept. Neuroscience Chemistry, Pfizer Global Research & Development, Eastern Point Rd., 06340, Groton CT, MS, 8220/4339, USA

    Matthew M. Hayward

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© 2009 Springer-Verlag Berlin Heidelberg

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Pellecchia, M. (2009). NMR Spectroscopy in Fragment Based Drug Design. In: Hayward, M.M., et al. Lead-Seeking Approaches. Topics in Medicinal Chemistry, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7355_2009_5

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