Contemporary Issues In ToxicologyRate of Neurotoxicant Exposure Determines Morphologic Manifestations of Distal Axonopathy
References (84)
- et al.
Formation of hemoglobin adducts of acrylamide and its epoxide metabolite glycidamide in the rat
Toxicol. Appl. Pharmacol.
(1991) - et al.
The impact of dose rate on the neurotoxicity of acrylamide: The interaction of administered dose, target tissue concentrations, tissue damage, and functional effects
Toxicol. Appl. Pharmacol.
(1996) Molecular mechanism of diketone neurotoxicity
Chem.–Biol. Interact.
(1985)- et al.
The relative neurotoxicity of methyl-n-butyl ketone, n-hexane and their metabolites
Toxicol. Appl. Pharmacol.
(1980) Inhibition of sodium-potassium-ATPase: A potentially ubiquitous mechanism contributing to central nervous system neuropathology
Brain Res. Rev.
(1991)- et al.
Mechanisms of injury-induced calcium entry in peripheral nerve axons: In vitro anoxia and ouabain exposure
Brain Res.
(1995) - et al.
Axonal atrophy is a specific component of 2,5-hexanedione peripheral neuropathy
Toxicol. Appl. Pharmacol.
(1995) - et al.
Biochemical and morphologic characterization of acrylamide peripheral neuropathy
Toxicol. Appl. Pharmacol.
(1998) - et al.
Acrylamide disrupts elemental composition and water content of rat tibial nerve: I. Myelinated axons
Toxicol. Appl. Pharmacol.
(1992) - et al.
Acrylamide disrupts elemental composition and water content of rat tibial nerve: III. Recovery
Toxicol. Appl. Pharmacol.
(1993)
Mechanism of calcium entry during axon injury and degeneration
Toxicol. Appl. Pharmacol.
In vitro acrylamide exposure alters growth cone morphology
Toxicol. Appl. Pharmacol.
Axonal transport of neurofilament is accelerated in peripheral nerve during 2,5-hexanedione intoxication
Brain Res.
The origin and nature of beading: A reversible transformation of the shape of nerve fibers
Prog. Neurobiol.
dl-versus meso-3,4-dimethyl-2,5-hexanedione: A morphometric study of the proximodistal distribution of axonal swellings in the anterior root of the rat
Toxicol. Appl Pharmacol.
Effects of neurofilamentous axonopathy-producing neurotoxicants on in vitro production of ATP by brain mitochondria
Brain Res.
Neurotoxicity of glycidamide, an acrylamide metabolite, following intraperitoneal injections in rats
J. Toxicol. Environ. Health
The effect of 3,4-dimethyl substitution on the neurotoxicity of 2,5-hexanedione. I. Accelerated clinical neuropathy is accompanied by more proximal axonal swellings
Toxicol. Appl. Pharmacol.
Formation of acrylamide (ACR) and glycidamide (GLY) hemoglobin adducts in ACR-exposed rats
Toxicologist
Human peripheral nerve disease (peripheral neuropathies)
Acrylamide neuropathy: Changes in composition of proteins of fast axonal transport resemble those observed in regenerating axons
J. Neurochem.
Axoplasmic flow in axonal neuropathies. I. Axoplasmic flow in cats with toxic neuropathies
Brain
Acrylamide and glycidamide impair neurite outgrowth in differentiation N1E.115 neuroblastoma without disturbing rapid bi-directional transport of organelles observed by video microscopy
J. Neurochem.
Nerve conduction slowing precedes demyelination in experimental n-butyl ketone (MBK) neuropathy
Subchronic toxicity of acrylamide administered to rats in drinking water followed by up to 144 days of recovery
J. Environ. Pathol. Toxicol.
The significance of the “dying-back” process in experimental and human neurological disease
Int. Rev. Exp. Pathol.
Ultrastructural features of the Purkinje cell damage caused by acrylamide in the rat: A new phenomenon in cellular neurophysiology
J. Neurocytol.
γ-Diketone peripheral neuropathy. II. Neurofilament subunit content
Toxicol. Appl. Pharmacol.
Toxicity and the metabolism of the neurotoxic hexacarbons n-hexane, 2-hexanone and 2,5-hexanedione
Annu. Rev. Pharmacol. Toxicol.
Peripheral neuropathy in rats produced by acrylamide
Br. J. Ind. Med.
Neurofilament redistribution in transected nerves: Evidence for bi-directional transport of neurofilaments
J. Neurosci.
Regulation of aberrant neurofilament phosphorylation in neuronal perikarya. II. Correlation with continued axonal elongation following axotomy
J. Neuropathol. Exp. Neurol.
Somatofugal axonal atrophy precedes development of axonal degeneration in acrylamide neuropathy
Arch. Toxicol.
Neurotrophic function in normal nerves and in peripheral neuropathies
Pathogenetic studies of hexane and carbon disulfide neurotoxicity
Crit. Rev. Toxicol.
Toxic neurofilamentous axonopathies and fast axonal transport. V. Reduced bidirectional vesicle transport in cultured neurons by acrylamide and glycidamide
J. Environ. Health Toxicol.
Acrylamide-induced alterations in axonal transport
Mol. Neurobiol.
The axon reaction in spinal ganglion neurons of acrylamide-treated rats
Acta Neuropathol.
Changes in Na-K ATPase and protein kinase C activities in peripheral nerve of acrylamide-treated rats
J. Toxicol. Environ. Health
Cited by (37)
Relationship between antioxidants and acrylamide formation
2023, Acrylamide in FoodRelationship between Antioxidants and Acrylamide Formation
2016, Acrylamide in Food: Analysis, Content and Potential Health EffectsDevelopment of new indole-derived neuroprotective agents
2011, Bioorganic and Medicinal ChemistryCitation Excerpt :The in vivo neuroprotective effect of TRP and the novel synthesized indole derivatives, 9b, 12c, 14a, and 17, against ACR-induced neurotoxicity in rats was investigated. ACR is a well established agent for induction of neurotoxicity.20,21 Neuronal damage due to ACR was detected by measuring: (1) the levels of brain monoamines, adrenaline (AD), noradrenalin (NA) and dopamine (DA), (2) the end product of brain lipid peroxidation, malondialdehyde, (MDA), (3) the activity of brain antioxidative enzymes, glutathione peroxidase (GPx), superoxide dismutase (SOD), and glutathione content (GSH), and (4) the activity of brain enzymes lactate dehydrogenase (LDH) and creatine kinase (CK).
The toxicity of hexanedione isomers in neural and astrocytic cell lines
2006, Environmental Toxicology and Pharmacology
- 1
To whom correspondence should be addressed at Montefiore Medical Center, Anesthesia Research–Moses 7, 111 E. 210th St., Bronx, NY 10467-2490. Fax: (718) 515-4903; E-mail: [email protected].