Regular ArticleDetermination of Parameters Responsible for Pharmacokinetic Behavior of TCDD in Female Sprague–Dawley Rats☆,☆☆
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The research described in this article has been funded in part by the US Environmental Protection Agency Cooperative Training Agreement (T-901915-02) with the University of North Carolina, Chapel Hill, NC 27599-7270. The manuscript was reviewed in accordance with US Environmental Protection Agency policy and approved for publication. However, it does not necessarily reflect the views of the Agency. Mention of trade names or commercial products does not constitute endorsement or use recommendation.
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Nomenclature: a, fraction delivered by lymph; Ah, Ah receptor concentration (nm); Bio, bioavailability; C, concentration (nmol/g); Dor, oral dose; f, volume fraction; h, Hill coefficient; ICA2, Michaelis-Menten constant of CYP1A2 induction (nm); InA2, maximum induction fold over basal synthesis rate of CYP1A2; K0, CYP1A2 basal synthesis rate (nmol/g/hr); K2, CYP1A2 degradation rate (nmol/g/hr); KAB, linear binding constant of TCDD to plasma proteins; KAbs, absorption rate from lumen (1/hr); KDAh, dissociation binding constant of TCDD-Ah (nm); KDA2, dissociation binding constant of TCDD-CYP1A2 (nm); Kn, linear binding of TCDD to any constituent in the intracellular domain; KS, distribution ratio of TCDD in lipid/water in the intracellular domain; KSt, stomach emptying rate (1/hr); KT, elimination rate of TCDD from the tissue (1/hr); M, amount (nmol); P, equilibrium distribution ratio; PA, permeability*area (ml/hr); Prj, general symbol for proteins; Q, blood flow rate (ml/hr); W, weight (g); A2, CYP1A2; A2BS, CYP1A2 basal concentration; Ah, Ah receptor; B, blood; f (subscript), free concentration; F, fat; K, kidney; Lip, lipid content; Li, liver; Lu, lung; Lum, lumen; nb, linear binding constituent; S, skin; Sp, spleen; St, stomach; Re, the rest of the body; T, tissue; t, total; W (subscript), water.
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