Rodent models of lymphocyte migration

doi:10.1006/smim.1999.0164

Seminars in Immunology

Volume 11, Issue 2, April 1999, Pages 85-93

https://doi.org/10.1006/smim.1999.0164 Get rights and content

Abstract

The ability of leukocytes to migrate out of blood into tissues enables them to perform their surveillance functions. Understanding the molecular mechanisms by which this migration is accomplished has the potential of unveiling new methods of regulating immune responses. The existing knowledge of rodent physiology and the recent development of knockout mice makes rodents attractive models for studying the mech- anisms of leukocyte migration in vivo. This review considers the existing rodent models in light of the knowledge gained from them in lymphocyte migration, and in addition, shows the advantages and limitations of using rodent models in studying lymphocyte migration.

References (84)

TB Issekutz et al.
Lymphocyte traffic through granulomas: difference in the recovery of indium111-labeled lymphocytes in afferent and efferent lymph
Cell Immunol
(1980)
TA Springer
Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
Cell
(1994)
MP Bevilacqua et al.
Selectins: A family of adhesion receptors
Cell
(1991)
TM Carlos et al.
Leukocyte-endothelial adhesion molecules
Blood
(1994)
LJ Picker et al.
The neutrophil selectin LECAM-1 presents carbohydrate ligands to the vascular selectins ELAM-1 and GMP-140
Cell
(1991)
KH Lee et al.
Memory T lymphocytes' adherence to interferon gamma-activated human dermal microvascular endothelial cells via E-selectin
J Dermatol Sci
(1995)
MA Labow et al.
Characterization of E-selectin-deficient mice: demonstration of overlapping function of the endothelial selectins
Immunity
(1994)
ND Staite et al.
Inhibition of delayed-type contact hypersensitivity in mice deficient in both E-selectin and P-selectin
Blood
(1996)
TB Issekutz et al.
T lymphocyte migration to arthritic jo ints and dermal inflammation in the rat: Differing migration patterns and the involvement of VLA-4
Clin Immunol Immunopathol
(1991)
C Berlin et al.
Alpha 4 integrins mediate lymphocyte attachment and rolling under physiologic flow
Cell
(1995)

A Weller et al.

Cloning of the mouse endothelial selectins. Expression of both E- and P-selectin is inducible by tumor necrosis factor alpha

J Biol Chem

(1992)

N Todoroki et al.

Enhancement by IL-1 and IFN-gamma of platelet activation: adhesion to leukocytes via GMP-140/PADGEM protein (SD62)

Biochem Biophys Res Commun

(1991)

MA Arnaout

Structure and function of the leukocyte adhesion molecules CD11/CD18

Blood

(1990)

MJ Elices et al.

VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site

Cell

(1990)

JL Gowans et al.

The recirculation of lymphocytes in the rat

Proc R Soc London Ser B

(1964)

JB Smith et al.

The traffic of cells through tissues: a study of peripheral lymph in sheep

J Anat

(1970)

CR MacKay et al.

Altered patterns of T cell migration through lymph nodes and skin following antigen challenge

Eur J Immunol

(1992)

DA Jones et al.

A two-step adhesion cascade for T cell/endothelial cell interactions under flow conditions

J Clin Invest

(1994)

R Alon et al.

The integrin VLA-4 supports tethering and rolling in flow on VCAM-1

J Cell Biol

(1995)

WA Muller et al.

PECAM-1 is required for transendothelial migration of leukocytes

J Exp Med

(1993)

M Subramaniam et al.

Reduced recruitment of inflammatory cells in a contact hypersensitivity response in P-selectin-deficient mice

J Exp Med

(1995)

EJ Kunkel et al.

Distinct phenotype of E-selectin-deficient mice. E-selectin is required for slow leukocyte rolling in vivo

Circ Res

(1996)

D Vestweber

Ligand-specificity of the selectins

J Cell Biochem

(1996)

MP Bevilacqua et al.

Selectins

J Clin Invest

(1993)

RS Larson et al.

Structure and function of leukocyte integrins

Immunol Rev

(1990)

A Sonnenberg

Integrins and their ligands

Curr Top Microbiol Immunol

(1993)

WM Gallatin et al.

A cell-surface molecule involved in organ-specific homing of lymphocytes

Nature

(1983)

DM Lewinsohn et al.

Leukocyte-endothelial cell recognition: evidence of a common molecular mechanism shared by neutrophils, lymphocytes, and other leukocytes

J Immunol

(1987)

PR Streeter et al.

Immunohistologic and functional characterization of a vascular addressin involved in lymphocyte homing into peripheral lymph nodes

J Cell Biol

(1988)

O Zollner et al.

L-selectin from human, but not from mouse neutrophils binds directly to E-selectin

J Cell Biol

(1997)

P Pizcueta et al.

Monoclonal antibody blockade of L-selectin inhibits mononuclear leukocyte recruitment to inflammatory sites in vivo

Am J Pathol

(1994)

TF Tedder et al.

L-selectin-deficient mice have impaired leukocyte recruitment into inflammatory sites

J Exp Med

(1995)

MP Bevilacqua et al.

Identification of an inducible endothelial-leukocyte adhesion molecule

Proc Natl Acad Sci USA

(1987)

A Levinovitz et al.

Identification of a glycoprotein ligand for E-selectin on mouse myeloid cells

J Cell Biol

(1993)

P Kotovuori et al.

The vascular E-selectin binds to the leukocyte integrins CD11/CD18

Glycobiology

(1997)

EL Berg et al.

The cutaneous lymphocyte antigen is a skin lymphocyte homing receptor for the vascular lectin endothelial cell–leukocyte adhesion molecule 1

J Exp Med

(1991)

LJ Picker et al.

A unique phenotype of skin-associated lymphocytes in humans: Preferential expression of the HECA-452 epitope by benign and malignant T cells at cutaneous sites

Am J Pathol

(1990)

LJ Picker et al.

ELAM-1 is an adhesion molecule for skin-homing T cells

Nature

(1991)

H Rossiter et al.

Skin disease-related T cells bind to endothelial selectins: expression of cutaneous lymphocyte antigen (CLA) predicts E-selectin but not P-selectin binding

Eur J Immunol

(1994)

RM Binns et al.

The role of E-selectin in lymphocyte and polymorphonuclear cell recruitment into cutaneous delayed hypersensitivity reactions in sensitized pigs

J Immunol

(1996)

A Silber et al.

Recruitment of lymphocytes during cutaneous delayed hypersensitivity in nonhuman primates is dependent on E-selectin and vascular cell adhesion molecule 1

J Clin Invest

(1994)

Cited by (13)

Manipulating the healing response
2016, Wound Healing Biomaterials
The skin is a fundamental barrier that interfaces with the environment, constituting the first line of defense from physical, chemical, and biological attacks. To counteract the insults multiple and complex pathway systems have evolved and been built up in the skin. Skin injuries, such as wounds, induce a highly dynamic repair program starting from inflammation and moving to tissue formation and maturation, where specific cell–cell and cell–matrix interactions, cytokines, and growth factors, in collaboration, aim to recover its integrity and homeostasis. In this context the inflammatory response plays a key role in directing the outcome of the wound healing response that is otherwise unbalanced in the chronic repair process, especially in patients with diabetes. The management of chronic wounds will be discussed, trying to ameliorate the comprehension of the relationships among the cellular types occurring in the healing process.
Manipulating the healing response
2016, Wound Healing Biomaterials: Therapies and Regeneration: Volume 1
The skin is a fundamental barrier that interfaces with the environment, constituting the first line of defense from physical, chemical, and biological attacks. To counteract the insults multiple and complex pathway systems have evolved and been built up in the skin. Skin injuries, such as wounds, induce a highly dynamic repair program starting from inflammation and moving to tissue formation and maturation, where specific cell–cell and cell–matrix interactions, cytokines, and growth factors, in collaboration, aim to recover its integrity and homeostasis. In this context the inflammatory response plays a key role in directing the outcome of the wound healing response that is otherwise unbalanced in the chronic repair process, especially in patients with diabetes. The management of chronic wounds will be discussed, trying to ameliorate the comprehension of the relationships among the cellular types occurring in the healing process.
Inflammation in wound repair: Molecular and cellular mechanisms
2007, Journal of Investigative Dermatology
Citation Excerpt :
Adhesion molecules which are crucial for neutrophil diapedesis include endothelial P- and E-selectins as well as the ICAM-1, -2. These adhesins interact with integrins present at the cells surface of neutrophils including CD11a/CD18 (LFA-1), CD11b/CD18 (MAC-1), CD11c/CD18 (gp150, 95), and CD11d/CD18 (Kulidjian et al., 1999). Chemokines and their receptors are most likely crucial mediators for neutrophil recruitment during repair (Gillitzer and Goebeler 2001; Esche et al., 2005).
In post-natal life the inflammatory response is an inevitable consequence of tissue injury. Experimental studies established the dogma that inflammation is essential to the establishment of cutaneous homeostasis following injury, and in recent years information about specific subsets of inflammatory cell lineages and the cytokine network orchestrating inflammation associated with tissue repair has increased. Recently, this dogma has been challenged, and reports have raised questions on the validity of the essential prerequisite of inflammation for efficient tissue repair. Indeed, in experimental models of repair, inflammation has been shown to delay healing and to result in increased scarring. Furthermore, chronic inflammation, a hallmark of the non-healing wound, predisposes tissue to cancer development. Thus, a more detailed understanding in mechanisms controlling the inflammatory response during repair and how inflammation directs the outcome of the healing process will serve as a significant milestone in the therapy of pathological tissue repair. In this paper, we review cellular and molecular mechanisms controlling inflammation in cutaneous tissue repair and provide a rationale for targeting the inflammatory phase in order to modulate the outcome of the healing response.
Antibody, cytokine and cytotoxic T lymphocyte responses in chimpanzees immunized with human papillomavirus virus-like particles
2001, Vaccine
We evaluated antibody, cytokine (IFN-γ, IL-5, TNF-α), and cytotoxic T lymphocyte (CTL) responses in chimpanzees immunized with monovalent or quadrivalent (HPV-6, -11, -16, -18) L1 virus-like particle (VLP) vaccines administered i.m. on aluminum hydroxyphosphate (alum) at weeks 0, 8 and 24. Maximum serum antibody titers to type-specific, neutralizing, conformational epitopes on HPV-11 or -16 L1 VLPs were detected by radioimmunoassay (RIA) four weeks after the second and third immunizations. HPV-11 and -16 neutralizing antibodies were also detected at similar time points with an Human papillomaviruses (HPV) neutralization assay using pseudovirions. Depending on the VLP type used for immunization, HPV type-specific cytokine responses were most frequently seen four weeks after the second or third immunizations and between weeks 44–52. Transient HPV-16 L1-specific CTL activity was observed only between weeks 16–24 in 3 of 22 (13.6%) chimpanzees immunized with HPV-16 L1 VLPs. These findings provide evidence that immunization with multivalent L1 VLPs on alum can evoke both neutralizing antibodies and Th1 and Th2 cytokine responses to several HPV types; however, induction of CTLs is infrequent.
Chronic inflammation and cancer: Potential chemoprevention through nuclear factor kappa B and p53 mutual antagonism
2014, Journal of Inflammation (United Kingdom)
Fatalities in natalizumab treatment - A 'no go' for leukocyte recirculation approaches?
2006, Expert Opinion on Therapeutic Targets

View all citing articles on Scopus

View full text

Regular ArticleRodent models of lymphocyte migration

Abstract

Cell Immunol

Cell

Cell

Blood

Cell

J Dermatol Sci

Immunity

Blood

Clin Immunol Immunopathol

Cell

J Biol Chem

Biochem Biophys Res Commun

Blood

Cell

The recirculation of lymphocytes in the rat

Proc R Soc London Ser B

The traffic of cells through tissues: a study of peripheral lymph in sheep

J Anat

Altered patterns of T cell migration through lymph nodes and skin following antigen challenge

Eur J Immunol

A two-step adhesion cascade for T cell/endothelial cell interactions under flow conditions

J Clin Invest

The integrin VLA-4 supports tethering and rolling in flow on VCAM-1

J Cell Biol

PECAM-1 is required for transendothelial migration of leukocytes

J Exp Med

Reduced recruitment of inflammatory cells in a contact hypersensitivity response in P-selectin-deficient mice

J Exp Med

Distinct phenotype of E-selectin-deficient mice. E-selectin is required for slow leukocyte rolling in vivo

Circ Res

Ligand-specificity of the selectins

J Cell Biochem

Selectins

J Clin Invest

Structure and function of leukocyte integrins

Immunol Rev

Integrins and their ligands

Curr Top Microbiol Immunol

A cell-surface molecule involved in organ-specific homing of lymphocytes

Nature

Leukocyte-endothelial cell recognition: evidence of a common molecular mechanism shared by neutrophils, lymphocytes, and other leukocytes

J Immunol

Immunohistologic and functional characterization of a vascular addressin involved in lymphocyte homing into peripheral lymph nodes

J Cell Biol

L-selectin from human, but not from mouse neutrophils binds directly to E-selectin

J Cell Biol

Monoclonal antibody blockade of L-selectin inhibits mononuclear leukocyte recruitment to inflammatory sites in vivo

Am J Pathol

L-selectin-deficient mice have impaired leukocyte recruitment into inflammatory sites

J Exp Med

Identification of an inducible endothelial-leukocyte adhesion molecule

Proc Natl Acad Sci USA

Identification of a glycoprotein ligand for E-selectin on mouse myeloid cells

J Cell Biol

The vascular E-selectin binds to the leukocyte integrins CD11/CD18

Glycobiology

The cutaneous lymphocyte antigen is a skin lymphocyte homing receptor for the vascular lectin endothelial cell–leukocyte adhesion molecule 1

J Exp Med

A unique phenotype of skin-associated lymphocytes in humans: Preferential expression of the HECA-452 epitope by benign and malignant T cells at cutaneous sites

Am J Pathol

ELAM-1 is an adhesion molecule for skin-homing T cells

Nature

Skin disease-related T cells bind to endothelial selectins: expression of cutaneous lymphocyte antigen (CLA) predicts E-selectin but not P-selectin binding

Eur J Immunol

The role of E-selectin in lymphocyte and polymorphonuclear cell recruitment into cutaneous delayed hypersensitivity reactions in sensitized pigs

J Immunol

Recruitment of lymphocytes during cutaneous delayed hypersensitivity in nonhuman primates is dependent on E-selectin and vascular cell adhesion molecule 1

J Clin Invest

Regular Article
Rodent models of lymphocyte migration