Regular ArticleGenetic Organization of Antibiotic Resistance Genes (aac(6′)-lb, aadA, and oxa9) in the Multiresistance Transposon Tn1331
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LMB-1 producing Citrobacter freundii from Argentina, a novel player in the field of MBLs
2020, International Journal of Antimicrobial AgentsCitation Excerpt :The differences between these two plasmids are based on the resistance genes present next to the blaTEM-1A gene. Indeed, pKp145-11b harbored a Tn1331-like element that carried, in addition to blaTEM-1A gene, three other resistance genes blaOXA-9 gene, ant(3’)-Ia gene and aac(6’)-Ib gene [26], as previously described [27]. Finally, as reported, pKp145-11b had high nucleotide sequence identity with plasmid pKp41M (accession number KY781949), another IncM plasmid carried by a K. pneumoniae isolate recovered from a parrot in Brazil [26].
Aminoglycoside modifying enzymes
2010, Drug Resistance UpdatesCitation Excerpt :At the 3′ end of the gene, instead of the usual attC site, there is a copy of attI1*, which may have been formed by an illegitimate recombination event between the attC site located 3′ of aadA1 of an integron and the attI1 locus located 5′ of blaOXA-9 of another integron in which the blaOXA-9 gene cassette is adjacent to the 5′-conserved sequence (Sarno et al., 2002). The resulting structure defines a gene cassette consisting of aadA1-attI1* but that lacks the usual attC site, and another gene cassette that includes two genes aadA1-attI1*-blaOXA-9–attC (see Fig. 2A) (Ramirez et al., 2008; Sarno et al., 2002; Tolmasky, 1990; Tolmasky and Crosa, 1993). While the aadA1-attI1* gene cassette is excised by the IntI1 integrase at a very low frequency the gene cassette that includes both genes is fully functional (Ramirez et al., 2008).
Development of a miniaturised microarray-based assay for the rapid identification of antimicrobial resistance genes in Gram-negative bacteria
2008, International Journal of Antimicrobial AgentsCitation Excerpt :Also of interest was the detection of OXA-9-positive E. coli, which also carried aac(6′)-Ib and aadA1-like gene. A region within a Tn1331 transposon encoding blaOXA-9, aac(6′)-Ib and aadA-like genes was first identified in a clinical isolate of Klebsiella pneumoniae [19]. Therefore, the array may also be useful for detecting known linkages between genes.
Small Klebsiella pneumoniae Plasmids: Neglected Contributors to Antibiotic Resistance
2019, Frontiers in Microbiology