Brief ReportMemory Modulation by Post-training Glucose or Insulin Remains Evident at Long Retention Intervals
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Insulin-like growth factor 2 rescues aging-related memory loss in rats
2016, Neurobiology of AgingCitation Excerpt :Furthermore, among the insulin group of peptides, IGF-2 may represent a most highly effective candidate for memory enhancement and for rescuing memory and synaptic plasticity impairments in both young and aged subjects. In fact, to our knowledge, the effect of insulin as a memory enhancer has been reported to be controversial (Clayson, 1971; Kopf and Baratti, 1996, 1999; Kopf et al., 1998; Moosavi et al., 2006; Schwarzberg et al., 1989). Moreover, although insulin produces changes in proliferation of new cells and synaptic molecular pathways in aged animals, it enhances memory only in young but not aged populations, suggesting that it may protect against neuronal loss, but may not reliably improve memory performance in aging (Haas et al., 2015).
Chemotherapy-induced long-term alteration of executive functions and hippocampal cell proliferation: Role of glucose as adjuvant
2014, NeuropharmacologyCitation Excerpt :Indeed, the alteration of executive functions was not observed when 5-FU was administered with glucose, and it is shown that glucose prevented the long-term 5-FU-induced decrease of hippocampal cell proliferation. In a good agreement with our observations, it was shown that acute administration of glucose facilitates memory performances of humans with high or altered cognitive functioning (Korol, 2002) and improve learning, strategy and memory in rodents when administered systemically (Messier, 1997; Kopf and Baratti, 1996; Schroeder and Packard, 2003) or centrally (Canal et al., 2005; Dash et al., 2006; Ragozzino et al., 1996; Kopf and Baratti, 1996). Thus, our study suggests that acute glucose administration may have counteracted the deleterious impact of 5-FU alone on cognitive functions and hippocampal cell proliferation and could explain the lack of cognitive deficits with the combination 5-FU/oxaliplatin.
The effect of intrahippocampal insulin microinjection on spatial learning and memory
2006, Hormones and BehaviorThe influence on cognition of the interaction between the macro-nutrient content of breakfast and glucose tolerance
2006, Physiology and Behavior