Elsevier

NeuroImage

Volume 17, Issue 2, October 2002, Pages 999-1009
NeuroImage

Regular Article
A H215O Positron Emission Tomography Study on Mental Imagery of Movement Sequences—The Effect of Modulating Sequence Length and Direction

https://doi.org/10.1006/nimg.2002.1139Get rights and content

Abstract

Motor imagery is a state of mental rehearsal of single movements or movement patterns and has been shown to recruit motor networks overlapping with those activated during movement execution. We wished to examine whether the brain areas subserving control of sequential processes could be delineated by pure mental imagery, their activation levels reflecting the processing demands of a sequential task. We studied six right-handed volunteers (39.0 ± 14 years) with H215O positron emission tomography (PET) while they continuously mentally pursued with their right hand one of five sequences differing in complexity (i.e., increases in sequence length, single-finger repetitions, and reversals). Conditions were repeated twice, alternating with two rest scans. Each imagined single motor element was paced at a frequency of 1 Hz. Significant activation increases (P < 0.05, corrected) associated with imagination of right finger movement sequences (conditions I to V combined)—compared to the rest condition—were observed in left sensorimotor cortex (M1/S1) and the adjacent inferior parietal cortex. Further activation increases (P < 0.001, uncorrected) occurred in bilateral dorsal premotor (PMd) cortex, left caudal supplementary motor area, bilateral ventral premotor cortex, right M1, left superior parietal cortex, left putamen, and right cerebellum. Activation decreases occurred in bilateral prefrontal and right temporo-occipital cortex. Activation increases that correlated with sequence complexity were observed only in specific areas of the activated network, notably in left PMd, right superior parietal cortex, and right cerebellar vermis (P < 0.05, corrected). In conclusion, our study, by varying the sequence structure of imagined finger movements, identified task-related activity changes in parietopremotor–cerebellar structures, reflecting their role in mediating sequence control.

References (93)

  • K.M. Lee et al.

    Subregions within the supplementary motor area activated at different stages of movement preparation and execution

    NeuroImage

    (1999)
  • M. Lepage et al.

    Frontal cortex and the programming of repetitive tapping movements in man: Lesion effects and functional neuroimaging

    Brain Res. Cognit. Brain Res.

    (1999)
  • R.C. Oldfield

    The assessment and analysis of handedness: The Edinburgh Inventory

    Neuropsychologia

    (1971)
  • G. Pfurtscheller et al.

    Motor imagery activates primary sensorimotor area in humans

    Neurosci. Lett.

    (1997)
  • R. Roure et al.

    Imagery quality estimated by autonomic response is correlated to sporting performance enhancement

    Physiol. Behav.

    (1999)
  • A. Schnitzler et al.

    Involvement of primary motor cortex in motor imagery: A neuromagnetic study

    NeuroImage

    (1997)
  • J. Tanji

    The supplementary motor area in the cerebral cortex

    Neurosci. Res.

    (1994)
  • S. Van Oostende et al.

    FMRI studies of the supplementary motor area and the premotor cortex

    NeuroImage

    (1997)
  • B.E. Wexler et al.

    An fMRI study of the human cortical motor system response to increasing functional demands

    Magn. Reson. Imaging.

    (1997)
  • L. Yaguez et al.

    A mental route to motor learning: Improving trajectorial kinematics through imagery training

    Behav. Brain Res.

    (1998)
  • G. Allen et al.

    Attentional activation of the cerebellum independent of motor involvement

    Science

    (1997)
  • A. Bleasel et al.

    Surgical ablations of the mesial frontal lobe in humans

    Adv. Neurol.

    (1996)
  • H. Boecker et al.

    Role of the human rostral supplementary motor area and the basal ganglia in motor sequence control: Investigations with H215O PET

    J. Neurophysiol.

    (1998)
  • P. Brotchie et al.

    Motor function of the monkey globus pallidus. 2. Cognitive aspects of movement and phasic neuronal activity

    Brain

    (1991)
  • M.J. Catalan et al.

    The functional neuroanatomy of simple and complex sequential finger movements: A PET study

    Brain

    (1998)
  • Y.C. Chen et al.

    The functions of the medial premotor cortex. II. The timing and selection of learned movements

    Exp. Brain Res.

    (1995)
  • J. Decety et al.

    Mapping motor representations with positron emission tomography

    Nature

    (1994)
  • L. Deecke

    Electrophysiological correlates of movement initiation

    Rev. Neurol. (Paris)

    (1990)
  • L. Deecke et al.

    Timing function of the frontal cortex in sequential motor and learning tasks

    Hum. Neurobiol.

    (1985)
  • L. Deecke et al.

    Generation of movement-related potentials and fields in the supplementary sensorimotor area and the primary motor area

    Adv. Neurol.

    (1996)
  • M.P. Deiber et al.

    Mesial motor areas in self-initiated versus externally triggered movements examined with fMRI: Effect of movement type and rate

    J. Neurophysiol.

    (1999)
  • J.P. Dick et al.

    Simple and complex movements in a patient with infarction of the right supplementary motor area

    Mov. Disord.

    (1986)
  • R.P. Dum et al.

    The origin of corticospinal projections from the premotor areas in the frontal lobe

    J. Neurosci.

    (1991)
  • L. Ersland et al.

    Phantom limb imaginary fingertapping causes primary motor cortex activation: An fMRI study

    NeuroReport

    (1996)
  • L. Fadiga et al.

    Corticospinal excitability is specifically modulated by motor imagery: A magnetic stimulation study

    Neuropsychologia

    (1999)
  • P.C. Fletcher et al.

    Brain systems for encoding and retrieval of auditory–verbal memory. An in vivo study in humans

    Brain

    (1995)
  • M.P. Francescato et al.

    Does motor imagery involve the ipsilateral motor cortex?

    NeuroImage

    (1999)
  • I. Fried

    Electrical stimulation of the supplementary sensorimotor area

    Adv. Neurol.

    (1996)
  • K. Friston

    Analysing brain images: Principles and overview

  • K.J. Friston et al.

    The relationship between global and local changes in PET scans

    J. Cereb. Blood Flow Metab.

    (1990)
  • K.J. Friston et al.

    Spatial registration and normalization of images

    Hum. Brain Mapp.

    (1995)
  • K.J. Friston et al.

    Statistical parametric maps in functional imaging: A general linear approach

    Hum. Brain Mapp.

    (1995)
  • C. Gerloff et al.

    Stimulation over the human supplementary motor area interferes with the organization of future elements in complex motor sequences

    Brain

    (1997)
  • A.M. Gordon et al.

    Functional magnetic resonance imaging of motor, sensory, and posterior parietal cortical areas during performance of sequential typing movements

    Exp. Brain Res.

    (1998)
  • S.T. Grafton et al.

    Functional anatomy of human procedural learning determined with regional cerebral blood flow and PET

    J. Neurosci.

    (1992)
  • U. Halsband et al.

    The role of premotor cortex and the supplementary motor area in the temporal control of movement in man

    Brain

    (1993)
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