Regular ArticleNeurodegeneration Is Associated to Changes in Serum Insulin-like Growth Factors
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Molecular mechanisms and cellular events involved in the neuroprotective actions of estradiol. Analysis of sex differences
2019, Frontiers in NeuroendocrinologyCitation Excerpt :In addition, aging and brain pathology may also affect other components of estrogen neuroprotective signaling. For instance, plasma levels of IGF-1, which as we have discussed in this paper is a factor interacting with estradiol neuroprotective signaling, are decreased with aging and are altered under different neurological conditions in humans (Busiguina et al., 2000). In addition, a dissociation of the molecular interactions of ERs and IGF-1 receptors in caveolae has been detected in the brain of AD patients, suggesting an altered estradiol signaling in this pathology (Canerina-Amaro et al., 2017).
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