Regular ArticlePentoxifylline Reverses Oxidative Mitochondrial Defect in Claudicating Skeletal Muscle☆,☆☆
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A systematic review of muscle morphology and function in intermittent claudication
2017, Journal of Vascular SurgeryCitation Excerpt :There were seven papers with metabolic data available,13,21,22,25,28,29,35 each with a different methodologic assessment. Two papers21,25 used a drug therapy intervention (propionyl-l-carnitine and pentoxifylline for 12 weeks). The remaining five papers used a single stimulation test.
A Review of the Potential Local Mechanisms by Which Exercise Improves Functional Outcomes in Intermittent Claudication
2016, Annals of Vascular SurgeryRemote and local ischemic postconditioning further impaired skeletal muscle mitochondrial function after ischemia-reperfusion
2012, Journal of Vascular SurgeryGait variability patterns are altered in healthy young individuals during the acute reperfusion phase of ischemia-reperfusion
2010, Journal of Surgical ResearchCitation Excerpt :However, the ischemia-reperfusion condition does not alter gait variability to the same magnitude as PAD, which suggests that other manifestations of the pathophysiology of PAD are leading to additional differences. These additional increases in variability seen in PAD patients are likely due to underlying cellular abnormalities in the lower extremity muscles and nerves that have been demonstrated in these patients [32–35]. In previous biomechanical studies of gait in PAD patients, changes have been consistently documented at the ankle, with differences in kinematics [12, 36], kinematic variability [8], and peak plantar flexion torque at late stance [11] between PAD patients and healthy matched controls.
Multifactorial Determinants of Functional Capacity in Peripheral Arterial Disease. Uncoupling of Calf Muscle Perfusion and Metabolism
2009, Journal of the American College of Cardiology
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Presented at the Annual Meeting of the Association for Academic Surgery, Philadelphia, Pennsylvania, November 18–20, 1999.
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This work was supported by funds provided by the Henry Ford Health System.