Regular ArticleThe Microvascular Structure of the Normal Colon in Rats and Humans
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An on-chip model of protein paracellular and transcellular permeability in the microcirculation
2019, BiomaterialsCitation Excerpt :Due to a small amount of cell sedimentation during fibrin polymerization, larger vessels may be observed at the bottom of the device. The volumetric density of the networks, φv, defined as the ratio between MVNs’ and total volume (Vv/Vtot), is approximately 20% and within the range expected in vivo (8–21% [18,19]), while the vascular surface area per volume available for transport, S = Sv/Vtot, is close in magnitude to the range expected for tissues like the human brain (4500 m−1 compared to 7000 m−1 [20]). The morphological similarities to the normal human endothelium include, most importantly, the presence of open lumens, which can be perfused from the side channels with any molecule dissolved in the cell culture medium or other liquid.
Influence of anatomical subsite on the incidence of microsatellite instability, and KRAS and BRAF mutation rates in patients with colon carcinoma
2012, Pathology Research and PracticeCitation Excerpt :There are studies which demonstrated that also nutrients have different effects on carcinogenesis in distinct parts of the large intestine. In addition, it is known that even adult mucosal epithelium of various parts of the ‘normal’ colon can be distinguished by their pattern of gene expression. [3,4,13–15,26]. However, the impact of these factors requires further investigation and should be the focus of further research.
Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, Part 1: Oral solutions
2011, Journal of Pharmaceutical SciencesCitation Excerpt :Otherwise, the intracellular volume of the epithelial cells would be considerably overestimated, which would in turn impair the prediction of gut wall metabolism. The fraction of the vascular space within the mucosa was estimated from the reported volume of the vasculature within the colonic mucosa of humans.112 After oral administration, the drug is transported along the lumen of the intestine according to the transit function and can enter the mucosa of the corresponding segment either by the transcellular route directly into the enterocytes or by paracellular diffusion into the interstitial space of the mucosa.
Vasculature in the mouse colon and spatial relationships with the enteric nervous system, glia, and immune cells
2023, Frontiers in Neuroanatomy