Elsevier

Genomics

Volume 73, Issue 2, 15 April 2001, Pages 232-237
Genomics

Regular Article
A Retrotransposon-Derived Gene, PEG10, Is a Novel Imprinted Gene Located on Human Chromosome 7q21

https://doi.org/10.1006/geno.2001.6494Get rights and content

Abstract

A novel paternally expressed imprinted gene, PEG10 (Paternally Expressed 10), was identified on human chromosome 7q21. PEG10 is located near the SGCE (Sarcoglycan ϵ) gene, whose mouse homologue was recently shown to be imprinted. Therefore, it is highly possible that a new imprinted gene cluster exists on human chromosome 7q21. Analysis of two predicted open reading frames (ORF1 and ORF2) revealed that ORF1 and ORF2 have homology to the gag and pol proteins of some vertebrate retrotransposons, respectively. These data suggest that PEG10 is derived from a retrotransposon that was previously integrated into the mammalian genome. PEG10 is likely to be essential for understanding how exogenous genes become imprinted.

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    Sequence data from this article have been deposited with the EMBL/GenBank Data Libraries under Accession No. AB049834.

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