A Genetic Linkage Map of the Baboon (Papio hamadryas) Genome Based on Human Microsatellite Polymorphisms

doi:10.1006/geno.2000.6245

Genomics

Volume 67, Issue 3, 1 August 2000, Pages 237-247

https://doi.org/10.1006/geno.2000.6245 Get rights and content

Abstract

A first-generation genetic linkage map of the baboon (Papio hamadryas) genome was developed for use in biomedical and evolutionary genetics. Pedigreed baboons (n = 694) were selected from the breeding colony maintained by the Southwest Foundation for Biomedical Research. To facilitate comparison with the human genome, the baboon linkage map consists primarily of human microsatellite loci amplified using published human PCR primers. Genotypes for 325 human microsatellites and 6 novel baboon microsatellites were used in linkage analyses performed with the MultiMap expert system. The resulting sex-averaged meiotic recombination map covers all 20 baboon autosomes, with average spacing among loci of 7.2 cM. Direct comparison among homologous (orthologous) loci reveals that, for 7 human autosomes, locus order is conserved between humans and baboons. For the other 15 autosomes, one or more rearrangements distinguish the two genomes. The total centimorgan distances among homologous markers are 28.0% longer in the human genome than in the baboon, suggesting that rates of recombination may be higher in humans. This baboon linkage map is the first reported for any nonhuman primate species and creates opportunities for mapping quantitative trait loci in baboons, as well as for comparative evolutionary analyses of genome structure.

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¹: To whom correspondence should be addressed at Department of Genetics, Southwest Foundation for Biomedical Research, P.O. Box 760549, San Antonio, TX 78227. Telephone: (210) 258-9532. Fax: (210) 670-3344. E-mail: [email protected].

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Regular ArticleA Genetic Linkage Map of the Baboon (Papio hamadryas) Genome Based on Human Microsatellite Polymorphisms

Abstract

Am. J. Hum. Genet.

Genomics

Genomics

Genomics

Curr. Opin. Genet. Dev.

Amer. J. Hum. Genet.

Genomics

Genomics

Genomics

Behavior predicts genetic structure in a wild primate group

Proc. Natl. Acad. Sci. USA

Baboon/human homologies examined by spectral karyotyping (SKY): A visual comparison

Cytogenet. Cell Genet.

Chromosome banding patterns of Papio papio

Ann. Genet.

Mamm. Genome

Human microsatellites applicable for analysis of genetic variation in apes and Old World monkeys

J. Hered.

A second-generation linkage map of the sheep genome

Mamm. Genome

A genetic map of the mouse with 4,006 simple sequence length polymorphisms

Nat. Genet.

Touchdown PCR to circumvent spurious priming during gene amplification

Nucleic Acids Res.

Comparison of the karyotypes of four Cercopithecoidea: Papio papio, P. anubis, Macaca mulatta and M. fascicularis

Cytogenet. Cell Genet.

Identity of the karyotypes of Papio papio and Macaca mulatta in R, G, C and Ag-NOR banding

Ann. Genet.

Report of the Committee on Comparative Gene Mapping

The 1993–94 Généthon human genetic linkage map

Nat. Genet.

Regular Article
A Genetic Linkage Map of the Baboon (Papio hamadryas) Genome Based on Human Microsatellite Polymorphisms