Regular ArticleIdentification of High-Molecular-Weight Proteins with Multiple EGF-like Motifs by Motif-Trap Screening☆
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2018, BoneCitation Excerpt :Identification at that time of its product designated sclerostin [12,19], and then recognition in 2005 that sclerostin binds to LRP5/6 thereby antagonizing canonical Wnt signaling [28], would represent a milestone in skeletal biology and provide a target (i.e. sclerostin inactivation) for osteoporosis treatment [29]. The gene responsible for SOST2 (LRP4) (OMIM 604270) [3], located on chromosome 11p12-p11.2, began characterization in 1998 [30]. Its relationship to SOST emerged in 2011 during genetic and molecular characterization of the first two patients with what came to be called SOST2 when LRP4 was discovered by Leupin et al. [4] to bind sclerostin (Table 1).
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Sequence data from this article have been deposited with the DDBJ Data Library under Accession Nos. human MEGF1, AB011535; human MEGF2, AB011536; human MEGF3, D87469; human MEGF4, AB011537; human MEGF5, AB011538; human MEGF6, AB011539; human MEGF7, AB011540; human MEGF8, AB011541; human MEGF9, AB011542; rat MEGF1, AB011527; rat MEGF2, AB011528; rat MEGF4, AB011530; rat MEGF5, AB011531; rat MEGF6, AB011532.
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