Regular ArticleLeishmaniaspp.: Mechanisms of Toxicity of Nitrogen Oxidation Products☆
References (58)
- et al.
Two high affinity nucleoside transporters inLeishmania donovani
Molecular and Biochemical Parasitology
(1987) - et al.
Inactivation of glutathione peroxidase by nitric oxide. Implication for cytotoxicity
Journal of Biological Chemistry
(1995) - et al.
Leishmania tropica:in vitro
Experimental Parasitology
(1979) - et al.
Nitric oxide production by human monocytes: Evidence for a role of CD23
Immunology Today
(1995) - et al.
Oxidation of critical cysteine residues of type I adenylyl cyclase byo
Journal of Biological Chemistry
(1994) - et al.
NO, thiols and disulfides
FEBS Letters
(1993) - et al.
Proline transport inLeishmania donovani
Molecular and Biochemical Parasitology
(1992) - et al.
Iron depletion: Possible cause of tumor cell cytotoxicity induced by activated macrophages
Biochemical and Biophysical Research Communications
(1984) - et al.
Stabilization of mitochondrial functions with digitonin
Methods in Enzymology
(1979) - et al.
Quenching of the tyrosyl free radical of ribonucleotide reductase by nitric oxide. Relationship to cytostasis induced in tumor cells by cytotoxic macrophages
Journal of Biological Chemistry
(1994)
Differential labeling of the erythrocyte hexose carrier byN
Biochimica et Biophysica Acta
Mechanism of covalent modification of glyceraldehyde-3-phosphate dehydrogenase at its active site thiol by nitric oxide, peroxynitrite and related nitrosating agents
FEBS Letters
Posttranslational modification of glyceraldehyde-3-phosphate dehydrogenase by S-nitrosylation and subsequent NADH attachment
Journal of Biological Chemistry
Activation of human macrophages for the killing of intracellularTrypanosoma cruzi
Immunology Letters
Nitric oxide toxicity in islet cells involves poly(ADP-ribose) polymerase activation and concomitant NAD+
Biochemical and Biophysical Research Communications
Nitric oxide kills hepatocytes by mobilizing mitochondrial calcium
Biochemical and Biophysical Research Communications
Nucleotide-selective cleavage of duplex DNA by nitric oxide
Biochemical and Biophysical Research Communications
Endogenous peroxynitrite is involved in the inhibition of mitochondrial respiration in immuno-stimulated J774.2 macrophages
Biochemical and Biophysical Research Communications
Transport of nutrients and ions across membranes of trypanosomatid parasites
Advances in Parasitology
Glucose transport inLeishmania donovani
Molecular and Biochemical Parasitology
Inhibition ofCryptococcus neoformans
Infection and Immunity
Nitric oxide and peroxynitrite
Methods in Nitric Oxide Research
The chemistry of nitric oxide and redox-related species
Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible
Journal of Clinical Investigation
Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results inl
Journal of Immunology
Effect of in vivo inhibition of nitric oxide production in murine leishmaniasis
Journal of Immunology
Donors of nitrogen oxides
Endogenous nitrogen oxides and bronchodilatorS
Proceedings of the National Academy of Sciences of the United States of America
Cited by (53)
Nitric oxide-loaded chitosan nanoparticles as an innovative antileishmanial platform
2019, Nitric Oxide - Biology and ChemistryCitation Excerpt :Thus, we hypothesize that the use of a higher dose (400 μM) could support parasite reduction for longer periods. This hypothesis was confirmed and we observed a noticeable and sustained promastigote killing even after 5 days, which corroborates with other studies, where high levels of NO were necessary to promote an efficient antiparasitic activity [43–45]. Before evaluation of drug efficiency against intracellular amastigotes, we evaluated the toxicity of NONPs on macrophages.
Leishmaniasis drug discovery: recent progress and challenges in assay development
2017, Drug Discovery TodayCitation Excerpt :Disadvantages include the need for specialised equipment and high running costs of flow-cytometry-based assays with limited capability for compound screening. To assess parasite viability, a 3[H] thymidine uptake assay was established for Leishmania enriettii and L. major promastigotes [89]. New strands of chromosomal DNA incorporate 3[H] thymidine during mitotic cell division.
Induction, Propagation, and Activity of Host Nitric Oxide: Lessons from Leishmania Infection
2015, Trends in ParasitologyCitation Excerpt :Moreover, NO cytotoxic effect in trans could explain how parasites are controlled by NO in fibroblasts that do not express iNOS during the latency phase of Leishmania infection [59]. Several studies have investigated the molecular mechanisms underlying NO cytotoxic activity on Leishmania parasites [60,61]. Addition of authentic NO gas or NO donors (such as acidified nitrite or S-nitroso-cysteines) in axenic promastigote or amastigote cultures leads to a rapid loss of parasite viability and to DNA fragmentation.
Antileishmanial activity and cytotoxicity of Brazilian plants
2014, Experimental ParasitologyLeishmania chagasi naturally resistant to nitric oxide isolated from humans and dogs with visceral leishmaniasis in Brazil
2012, Nitric Oxide - Biology and ChemistryRole of trypanosomatid's arginase in polyamine biosynthesis and pathogenesis
2012, Molecular and Biochemical ParasitologyCitation Excerpt :A different approach is to use NO or nitrosating compounds or NOS2-inducing agents. There is some evidence that sodium nitroprusside – a relatively strong nitrosating agent – acts as a nitric oxide (NO) donor, reducing L. amazonensis viability in vitro [124,125]. The second approach is more interesting and would prevail macrophages in a manner similar to the way Th1 activation acts to destroy the parasite burden.