Regular ArticleNeural Stem Cells Spontaneously Express Dopaminergic Traits after Transplantation into the Intact or 6-Hydroxydopamine-Lesioned Rat
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2021, Pharmacological ResearchCitation Excerpt :C17.2 are a prototypical and stable neural stem cell (NSC) line that is valuable for in vitro studies in understanding neural cell activity. Early reports indicated NSC line C17.2 can integrate into the central nervous system and as a potential therapeutic method for several neurodegenerative diseases [50–52]. Moreover, C17.2 cells have also been used as a model for some proteomics studies 53–55].
Cranial and related sensorimotor impairments in rodent models of Parkinson's disease
2012, Behavioural Brain Research(+)-Cholesten-3-one induces differentiation of neural stem cells into dopaminergic neurons through BMP signaling
2010, Neuroscience ResearchCitation Excerpt :Bcl-Xl and hematopoietic cytokines have been demonstrated to enhance the differentiation of NSCs into dopaminergic neurons (Liste et al., 2004; Carvey et al., 2001). However, following transplantation a small number of NSCs can spontaneously differentiate into neurons with a few expression dopaminergic traits (Yang et al., 2002). Bone morphogenetic proteins (BMPs), which are multi-functional growth factors that belong to the transforming growth factor beta (TGF-β) superfamily (Hogan, 1996), have diverse actions on the fate choice and differentiation of NSCs (Li et al., 1998; Mabie et al., 1999).
Neural stem cells for Parkinson’s disease management: Challenges, nanobased support, and prospects
2023, World Journal of Stem Cells
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