Regular ArticleThe Expression of GABA in Mossy Fiber Synaptosomes Coincides with the Seizure-Induced Expression of GABAergic Transmission in the Mossy Fiber Synapse
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Cited by (27)
The plastic neurotransmitter phenotype of the hippocampal granule cells and of the moss in their messy fibers
2016, Journal of Chemical NeuroanatomyCitation Excerpt :The last component of the molecular markers that define the GABAergic phenotype of the granule cells is the presence of GABA-specific membrane and vesicular transporters. Using immunohistological techniques, Frahm et al. (2000) determined the presence of the GABA membrane transporter (GAT-1) in the granule cells and Gómez-Lira et al. (2002) showed that MF terminals capture GABA and nipecotic acid blocks this uptake. The presence of GAT-1 was also corroborated by electrophysiological experiments showing that block of the GAT-1 prolonged GABAA-mediated synaptic responses of MF origin (Vivar and Gutiérrez, 2005).
Changes in hippocampal GABA<inf>A</inf>/cBZR density during limbic epileptogenesis: Relationship to cell loss and mossy fibre sprouting
2011, Neurobiology of DiseaseCitation Excerpt :MFS has been reported to make excitatory connections with GABAergic interneurons, potentially resulting in overall inhibition in the hippocampal circuit (Sloviter, 1992; Kotti et al., 1997; Sloviter et al., 2006). This may be a compensatory response in an attempt to suppress the seizure and may lead to enhanced synthesis and release of GABA from mossy fibre terminals (Gomez-Lira et al., 2002; Gutierrez, 2002). Here we found that at 6 weeks post-SE there was an inverse relationship between the magnitude of the MFS and maximal GABAA/cBZR density in the SM layer of the DG.
Mossy fiber synaptic transmission: communication from the dentate gyrus to area CA3
2007, Progress in Brain ResearchCitation Excerpt :Some GABAergic cells, immunocytochemically characterized by the presence of GAD67 or GABA, do not contain or contain traces of GAT-1, but not vice versa (Rattray and Priestley, 1993). However, it has been found that GAT-1 is also localized in the glutamatergic granule cells (Frahm et al., 2000; Sperk et al., 2003), and it controls GABA uptake to the MF terminals (Gomez-Lira et al., 2002) but not GABA release at this synapse (Vivar and Gutierrez, 2005; Safiulina et al., 2006). Because glutamate is a general metabolic substrate and serves as the precursor of inhibitory transmitter GABA, glutamate immunoreactivity is not specific to glutamatergic neurons.
Neurogenesis and Neuroenhancement in the Pathophysiology and Treatment of Bipolar Disorder
2007, International Review of NeurobiologyCitation Excerpt :Although most newly generated neurons in the DG are excitatory glutamatergic granule cells, GABAergic interneurons derived from adult progenitor cells have been found (Liu et al., 2003). Moreover, researchers finding neurogenesis in the rat cortex have proposed these cells to be distinctively GABAergic interneurons (Dayer et al., 2005) and adult excitatory granule cells can take on a GABAergic phenotype when treated with BDNF or after induction of seizures (Gomez‐Lira et al., 2002, 2005). These data along with the human postmortem findings indicating decreased hippocampal GABAergic interneurons in subjects with BPD (Heckers et al., 2002) give us good reason to further evaluate the role of GABAergic neurogenesis in BPD.
The dual glutamatergic-GABAergic phenotype of hippocampal granule cells
2005, Trends in Neurosciences
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To whom correspondence should be addressed at the Departamento de Fisiologı́a, Biofı́sica y Neurociencias, Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional, Apartado Postal 14-740, México, DF 07000, México. Fax: (52)55-5747-3754. E-mail: [email protected].