Regular ArticleInhibition of Corneal Neovascularization by Recombinant Adenovirus Mediated Antisense VEGF RNA
References (46)
- et al.
Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1
Blood
(1996) - et al.
Terminationsequence requirements vary among genes transcribed by RNA polymerase III
J. Molec. Biol
(1999) - et al.
Efficient adenovirus-mediated gene transfer into human blood monocyte-derived macrophages
Biochem. Biophys. Res. Commun
(1993) - et al.
VEGF145, a secreted vascular endothelial growth factor isoform that binds to extracellular matrix
J. Biol. Chem
(1997) - et al.
Retrovirus producer cells encoding antisense VEGF prolong survival of rats with intracranial gliomas
Int. J. Dev. Neurosci
(1999) - et al.
Overexpression of vascular endothelial growth factor (VEGF) in the retinal pigment epithelium leads to the development of choroidal neovascularization
Am. J. Pathol
(2000) - et al.
Vascular endothelial growth factor: a new member of the platelet-derived growth factor gene family
Biochem. Biophys. Res. Commun
(1989) - et al.
Thehuman gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing
J. Biol. Chem
(1991) - et al.
Gene transfer into human bone marrow hematopoietic cells mediated by adenovirus vectors
Blood
(1996) - et al.
Requirement for vascular endothelial growth factor in wound- and inflammation-related corneal neovascularization
Invest. Ophthalmol. Vis. Sci
(1998)
Modulation of invivo growth of thyroid tumor-derived cell lines by sense and antisense vascular endothelial growth factor gene
Oncogene
VEGF localisation in diabetic retinopathy
Br. J. Ophthalmol
Protection of a T-cell line from human immunodeficiency virus replication by the stable expression of a short antisense RNA sequence carried by a shuttle RNA molecule
J. Acquir. Immune Defic. Syndr. Hum. Retrovirol
Suppression of glioblastoma angiogenicity andtumorigenicity by inhibition of endogenous expressionof vascular endothelial growth factor
Proc. Nat.. Acad. Sci. U.S.A
Vascular permeability factor: atumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration
J. Exp. Med
Enhancer stimulation unmasks latent gene transfer after adenovirus-mediated gene delivery into human vascular smooth muscle cells
Circ. Res
Correlation of VEGF expression by leukocytes with the growth and regression of blood vessels in the rat cornea
Invest. Ophthalmol. Vis. Sci
Expression of small, therapeutic RNAs in human cell nuclei
Gene Ther
Manipulation of adenovirus vectors
Methods in Molecular Biology, Gene Transfer and Expression Protocols
Evaluation of promoter strength for hepatic gene expression in vivo following adenovirus-mediated gene transfer
Gene Ther
Cell-mediated immune response and stability of intraocular transgene expression after adenovirus-mediated delivery
Invest. Ophthalmol. Vis. Sci
The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA
Molec. Endocrinol
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2018, Survey of OphthalmologyCitation Excerpt :Subconjunctival injection of synthetic siRNAs was able to silence VEGF-A sequences and inhibit mouse corneal angiogenesis induced by alkali burn, showing 2.34 mm2 less neovascularized area than the uninjected controls.310 Utilizing a similar approach, shRNA or antisense oligonucleotide-mediated silencing of VEGF-A also effectively suppressed corneal neovascularization in murine models.161,229 Although clinical trials of VEGF siRNA for corneal neovascularization have not been reported, this approach is currently undergoing clinical evaluation to treat age-related macular degeneration.132,198,199
- f1
*Please note the first and second authors have contributed equally to this paper.
- f2
†Address correspondence to: P. E. Rakoczy, Lions Eye Institute, 2Verdun St, Nedlands WA 6009, Australia. E-mail: rakoczy@ cyllene.uwa.edu.au