Regular ArticleProliferating Cell Nuclear Antigen Bound to DNA Synthesis Sites: Phosphorylation and Association with Cyclin D1 and Cyclin A
References (0)
Cited by (67)
PCNA: A silent housekeeper or a potential therapeutic target?
2014, Trends in Pharmacological SciencesCell cycle and developmental regulations of replication factors in mouse embryonic stem cells
2005, Journal of Biological ChemistryCitation Excerpt :Similar phosphorylation-induced mobility shift of MCM4 protein during G2/M phase was previously observed in human somatic cells (27). The level of chromatin-bound PCNA protein increased during the S phase, consistent with its association with the sites of DNA replication (28, 29). It was previously reported that cyclin B1 is the only cyclin the level of which markedly fluctuates during the cell cycle of ES cells (3).
Rapamycin causes activation of protein phosphatase-2A<inf>1</inf> and nuclear translocation of PCNA in CD<sup>4+</sup> T cells
2004, Biochemical and Biophysical Research CommunicationsCitation Excerpt :The involvement of protein phosphatase-2A1 in the nuclear translocation of PCNA supports a phosphorylation event in the regulation of PCNA subcellular localization and therefore function. PCNA is known to be phosphorylated at a number of sites in vivo [34,35]. Protein phosphatase-2A1 may dephosphorylate PCNA at one of these sites or it may act indirectly via another protein to elicit the nuclear translocation of PCNA.