This paper considers the problem of devising a single stage procedure for selecting the treatment combination associated with the largest interaction in a two-factor r fx× c experiment having independent normally distributed observations with common known variance. The intuitive procedure based on the best linear unbiased estimators of the population interactions is employed. Initially an indifference zone formulation is used; the problem of determining the least favorable configuration is reduced to a nonlinear programming problem with log concave objective function and a convex polytope as feasible region. A solution technique is introduced in the context of an illustrative example. The problem is also considered using a preferred population formulation; this approach requires a strengthened version of the indifference zone probability requirement. It is shown that the same sample size guarantees this requirement as does the earlier one.