Biochemical and Biophysical Research Communications
Regular ArticleA Factor of Inducing IgE from a Filarial Parasite Prevents Insulin-Dependent Diabetes Mellitus in Nonobese Diabetic Mice☆
References (42)
- et al.
Immunoglobulin E synthesis in parasite infection
J. Allergy Clin. Immunol.
(1976) - et al.
Intestinal nematode parasites, cytokines and effector mechanisms
Int. J. Parasitol.
(1998) - et al.
Extensive diversity in repeat unit sequences of the cDNA encoding the polyprotein antigen/allergen from the bovine lungworm Dictyocaulus viviparus
Mol. Biochem. Parasitol.
(1995) - et al.
Loa loa: Structural diversity of a 15-kDa repetitive antigen
Exp. Parasitol.
(1995) - et al.
A surface-associated glycoprotein (gp15/400) from Brugia filarial parasites is composed of multiple tandemly repeated units and processed from a 400-kDa precursor
Exp. Parasitol.
(1993) Regulation of T helper type 2 cell immunity by interleukin-4 and interleukin-13
Pharmacol. Ther.
(2000)- et al.
Prevention of diabetes and insulitis in NOD mice by a single BCG vaccination
Diabetes Res. Clin. Pract.
(1990) - et al.
Possible mechanism of the preventive effect of BCG against diabetes mellitus in NOD mouse
Cell. Immunol.
(1991) - et al.
Immunology of human helminth infection
Int. Arch. Allergy Immunol.
(1996) - et al.
Recombinant Dirofilaria immitis-derived antigen can suppress passive cutaneous anaphylaxis
Int. Arch. Allergy Immunol.
(2001)
The relationship between immunological responsiveness controlled by T-helper 2 lymphocytes and infections with parasitic helminthes
Parasitology
IgE antibody to parasite induced in mice
Allergy
Th2-mediated host protective immunity to intestinal nematode infections
Philos. Trans. R. Soc. London B Biol. Sci.
Egg deposition is the major stimulus for production of Th2 cytokines in murine Schistosoma mansoni
J. Immunol.
Infection with Schistosoma mansoni prevents insulin dependent diabetes mellitus in non-obetic mice
Parasite Immunol.
Molecular cloning and characterization of a novel neutrophil chemotactic factor from a filarial parasite
Mol. Immunol.
Predominance of T lymphocytes in pancreatic islets and spleen of pre-diabetic (NOD) mice: A longitudinal study
Clin. Exp. Immunol.
Production and activities of IgE in helminth infection
Progr. Allergy
Effect of MHC transgene expression on spontaneous insulin autoantibody class switch in nonobese diabetic mice
Diabetes
The debate over the effector function of eosinophils in helminth infection: New evidence from studies on the regulation of vaccine immunity by IL-12
Mem. Inst. Oswaldo Cruz
Cited by (56)
Effect of macrophage polarization on parasitic protection against type 1 diabetes mellitus
2024, Experimental ParasitologyHelminth-Induced and Th2-Dependent Alterations of the Gut Microbiota Attenuate Obesity Caused by High-Fat Diet
2020, Cellular and Molecular Gastroenterology and HepatologyCitation Excerpt :The pathophysiology of obesity is multifactorial, and not completely understood. The protective effects of helminths on metabolic disorders have been attributed to the immunomodulatory effects of worms driving Th2 and regulatory immune responses,15,22,27 which have been linked to the amelioration of Th1- or Th17-mediated diseases.27–29 It has become increasingly clear that multiple facets of the Th2-associated immune response promote metabolic homeostasis.30,31
Combination of worm antigen and proinsulin prevents type 1 diabetes in NOD mice after the onset of insulitis
2016, Clinical ImmunologyCitation Excerpt :However, similar to the treatment with LsAg, other helminth-derived antigens like S. mansoni egg antigen were only shown to prevent or delay diabetes onset in NOD mice at 4–6 weeks of age. The same accounts to treatment with Dirofilaria immitis antigen, which completely prevented insulitis and diabetes onset only when given to 6-week-old female NOD mice [23] as well as for excretory-secretory products from Fasciola hepatica, which only protected NOD mice from diabetes onset when administered at 4 weeks of age [24]. It can be assumed that at later time points helminth antigen therapy has no effect, as inflammation of the pancreas progressed to a state where the immunomodulatory effects of helminth antigen treatment alone are not sufficient to prevent further loss of pancreatic islet cells.
Helminth therapy for organic diseases?
2015, Translational ResearchCitation Excerpt :Diabetes is also prevented by injection of Schistosome eggs in 5-week-old mice, highlighting the importance of the egg-directed Th2 response. As in other models, infection with a viable parasite is not necessary: Filaria and S. mansoni products injected in 4- to 6-week-old NOD mice completely prevent insulitis and diabetes development by impairing the anti-islet Th1 cell response.75,76 The protective effect is exerted in young mice around the age of 5 weeks, when islet antigens presentation in pancreatic lymph nodes begins gradually causing the infiltration of antigen-presenting cell and lymphocytes.77
The Protective Role of Helminths in Autoimmunity
2015, Infection and AutoimmunityVaccine against autoimmune disease: Can helminths or their products provide a therapy?
2013, Current Opinion in Immunology
- ☆
Abbreviations used: IgE, immunoglobulin E; rDiAg, recombinant DiAg; NOD, nonobese diabetic; IDDM, insulin-dependent diabetes mellitus.
- 1
To whom correspondence and reprint requests should be addressed. Fax: +81-3-5684-2849. E-mail: [email protected].