Biochemical and Biophysical Research Communications
Regular ArticleIdentification and Structure of the Nerve Growth Factor Binding Site on TrkA
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2019, European Journal of Medicinal ChemistryCitation Excerpt :In the final stage of LigPrep, compounds were minimized with OPLS-2001 Force field [75]. The Human nerve growth receptor structure with PDBID 1HE7 (Resolution- 2 Å) is downloaded from Protein Data Bank [76]. The protein structure was prepared using the ‘Protein Preparation Wizard’ of the Schrödinger suite (Schrödinger, LLC, New York, NY, 2009).
Predicting a double mutant in the twilight zone of low homology modeling for the skeletal muscle voltage-gated sodium channel subunit beta-1 (Na<inf>v</inf>1.4 β1)
2015, Computational and Structural Biotechnology JournalTreatment of murine osteoarthritis with TrkAd5 reveals a pivotal role for nerve growth factor in non-inflammatory joint pain
2010, PainCitation Excerpt :The sTNFR consisted of 2 murine p75 receptors fused to murine IgG2a and was produced as previously described [27]). The binding domain of the tyrosine kinase receptor (TrkAd5) has been shown to be the only domain of the TrkA receptor required for binding to NGF [30]. This small (13 kDa) soluble receptor domain is able to bind NGF with high affinity and issequester NGF, blocking its action on both receptors [37].
The Mechanism of NGF Signaling Suggested by the p75 and TrkA Receptor Complexes
2009, Handbook of Cell Signaling, Second Edition
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