Resveratrol, a Natural Product Present in Wine, Decreases Tumour Growth in a Rat Tumour Model

doi:10.1006/bbrc.1998.9916

Biochemical and Biophysical Research Communications

Volume 254, Issue 3, 27 January 1999, Pages 739-743

https://doi.org/10.1006/bbrc.1998.9916 Get rights and content

Abstract

Resveratrol administration to rats inoculated with a fast growing tumour (the Yoshida AH-130 ascites hepatoma) caused a very significant decrease (25%) in the tumour cell content. The effects of this diphenol were associated with an increase in the number of cells in the G₂/M cell cycle phase. Interestingly, flow cytometric analysis of the tumour cell population revealed the existence of an aneuploid peak (representing 28% of total), which suggests that resveratrol causes apoptosis in the tumour cell population resulting in a decreased cell number.

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Regular ArticleResveratrol, a Natural Product Present in Wine, Decreases Tumour Growth in a Rat Tumour Model

Abstract

Clin. Biochem.

Lancet

Clin. Chim. Acta

Am. J. Clin. Nutr.

Anal. Biochem.

Biochem. Biophys. Res. Commun.

Blood

Arch. Biochem. Biophys.

J. Immunol. Meth.

Exp. Cell. Res.