Biochemical and Biophysical Research Communications
Regular ArticleStimulation of DNA Polymerase γ Activity by Proliferating Cell Nuclear Antigen
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Cited by (6)
Further characterization of human DNA polymerase δ interacting protein 38
2005, Journal of Biological ChemistryCitation Excerpt :PCNA, which is generally considered to be a nuclear protein and whose functions are in the nucleus, has been reported to be able to stimulate mitochondrial polymerase γ activity (45). A more recent study (46) showed that monoclonal antibodies against PCNA specifically recognized a single band of 30 kDa in the mitochondria from the filamentous fungus and yeast. These studies suggest that PDIP38 might function in the mitochondria through its interaction with PCNA, even though the level of PCNA in mammalian mitochondria might be too low to be detected by Western blotting.
Stimulation of a mitochondrial endo-exonuclease from Podospora anserina by PCNA
2003, Biochemical and Biophysical Research CommunicationsCitation Excerpt :This size corresponds to the yeast PCNA pol30 gene product molecular weight of 28.4 kDa and to the fungal PCNA homolog, and thus further suggests the recognition specificity of this protein inside this organelle. In accordance with the detection in fungal mitochondria of a 30-kDa protein specifically recognized by anti-PCNA antibodies and the stimulation of the nuclease activity by the PCNA, a recent report described the 2–3-fold stimulation of the DNA polymerase γ activity from rat liver mitochondria and concomitantly the co-purification of immunostained PCNA revealed by immunoblotting in the polymerase γ fraction prepared from mt extracts [22]. We observed the same stimulation of mt DNA polymerase γ activity from P. anserina and S. cerevisiae (data not shown).
Increase in DNA Polymerase γ in the Hearts of Adriamycin- Administered Rats
2002, Experimental and Molecular PathologyProliferating cell nuclear antigen in normal and regenerating rat livers
1999, Experimental and Molecular PathologyAge-related changes in proliferating cell nuclear antigen levels
1996, Mechanisms of Ageing and Development