Regular ArticleIdentification of Several Isoforms of T-Kininogen Expressed in the Liver of Aging Rats
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Prospective highlights of serum glycoproteins in spontaneous tolerance after orthotopic liver transplantation
2011, Clinica Chimica ActaCitation Excerpt :In rats, five different isoforms of kininogen were identified. T-kininogen is a cysteine proteinase inhibitor and also serves as a reliable biomarker of the aging process in male Sprague–Dawley rats [20]. T-kininogen expression may indicate the involvement of vasodilatation, thereby favouring the deposition of immune complexes at the vascular level [21].
Kininogens: More than cysteine protease inhibitors and kinin precursors
2010, BiochimieCitation Excerpt :A unique protease inhibitor is over-expressed in prostate during senescence and corresponds to both T-I and T-II forms of TK [192]. No variation of HK expression was detected in prostates of senescent rats, while a greater HK level was reported in sera of aged rats [177]. While there is one report that HK rises linearly with age in humans [193], a possible age-related increase in the expression and function of human kininogens remains an intriguing question.
T-Kininogen present in the liver of old rats is biologically active and readily forms complexes with endogenous cysteine proteinases
1997, Mechanisms of Ageing and Development