Elsevier

Seminars in Cancer Biology

Volume 9, Issue 6, December 1999, Pages 387-395
Seminars in Cancer Biology

Regular Article
The interaction between p53 and papillomaviruses

https://doi.org/10.1006/scbi.1999.0142Get rights and content

Abstract

The p53 tumour suppressor is one of the host's principal defences against viral replication and subsequent cell transformation. The human papillomaviruses have evolved an elaborate strategy whereby the viral E6 proteins directly target p53 for ubiquitin mediated degradation and thus overcome the inhibitory effects of p53. However, a more detailed picture of the HPV*b1p53 interaction is now emerging in which there is a complex interplay between both positive and negative effectors of these interactions. This demonstrates the existence of a finely balanced virus*b1host relationship which, on rare occasion, fails and initiates the processes that ultimately lead to malignancy.

References (88)

  • C Staib et al.

    p53 inhibits JC virus DNA replication in vivo and interacts with JC virus large-T antigen

    Virology

    (1996)
  • T Mummenbrauer et al.

    p53 protein exhibits 3′-to-5′ exonuclease activity

    Cell

    (1996)
  • A Hiraiwa et al.

    Comparative study on E6 and E7 genes of some cutaneous and genital papillomaviuses of human origin for their ability to transform 3Y1 cells

    Virology

    (1993)
  • AF Burnett et al.

    Prognostic significance of polymerase chain reaction detected human papillomavirus of tumours and lymph nodes in surgically treated stage IB cervical cancer

    Gynecol Oncol

    (1992)
  • C Kühne et al.

    E3-ubiquitin ligase/E6-AP links multicopy maintenance protein 7 to the ubiquitination pathway by a novel motif, the L2G box

    J Biol Chem

    (1998)
  • Hausen H zur

    Viruses in human cancer

    Science

    (1991)
  • K Shah et al.

    Papillomaviruses,

  • E Schwarz et al.

    Structure and transcription of human papillomavirus sequences in cervical carcinoma cells

    Nature

    (1985)
  • LM Alvarez-Salas et al.

    Proc Natl Acad Sci USA

    (1998)
  • M Tommasino et al.

    Human Papillomavirus E6 and E7: proteins which deregulate the cell cycle

    BioEssays

    (1995)
  • JO Funk et al.

    Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein

    Genes Dev

    (1997)
  • K Zerfass-Thome et al.

    Inactivation of the cdk inhibitor p27KIP1by the human papillomavirus type 16 E7 oncoprotein

    Oncogene

    (1996)
  • Oncogene, reviews: 53, 1999, Jenkins, J,Banks,...
  • J Ruppert et al.

    Analysis of a protein-binding domain of p53

    Mol Cell Biol

    (1993)
  • J Lin et al.

    Several hydrophobic aminoacids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B-55kD protein

    Genes Dev

    (1994)
  • W Steegenga et al.

    The large E1B protein together with the E4orf6 protein target p53 for active degradation in adenovirus infected cells

    Oncogene

    (1998)
  • LW Elmore et al.

    Hepatitis B virus X protein and p53 tumour suppressor interactions in the modulation of apoptosis

    Proc Natl Acad Sci USA

    (1997)
  • M Scheffner et al.

    Interactions of human papillomavirus type 16 E6 oncoprotein with wild type and mutant human p53

    J Virol

    (1992)
  • J Huibregtse et al.

    A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 and 18

    EMBO J

    (1991)
  • J Huibregtse et al.

    L ocalisation of the E 6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins

    Mol Cell Biol

    (1993)
  • J Huibregtse et al.

    A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase

    Proc Natl Acad Sci USA

    (1995)
  • U Nuber et al.

    The ubiquitin-protein ligase E6-associated protein (E6-AP) serves as its own substrate

    Eur J Biochem

    (1998)
  • P Beer-Romero et al.

    Antisense targeting of E6AP elevates p53 in HPV-infected cells but not in normal cells

    Oncogene

    (1997)
  • S Gross-Mesilaty et al.

    Basal and human papillomavirus E6 oncoprotein-induced degradation of Myc proteins by the ubiquitin pathway

    Proc Natl Acad Sci USA

    (1998)
  • M Thomas et al.

    Inhibition of bak induced apoptosis by HPV-18 E6

    Oncogene

    (1998)
  • Gardiol, D, Kühne, C, Glausinger, B, Lee, S, Javier, R, B anks, L, 1999, Oncogenic Human papillomavirus E6 proteins...
  • A Storey et al.

    Role of a p53 polymorphism in the development of human papillomavirus-associated cancer

    Nature

    (1998)
  • X Li et al.

    High risk human papillomavirus E6 protein has two distinct binding sites within p53, of which only one determines degradation

    J Virol

    (1996)
  • Pim, D, Banks, L, 1999, HPV-18 E6*I protein modulates the E6-directed degradation of p53 by binding to full-lenght...
  • D Pim et al.

    Mutational analysis of HPV-18 E6 identifies domains required for p53 degradation in vitro, abolition of p53 transactivation in vivo and immortalisation of primary BMK cells

    Oncogene

    (1994)
  • D Gardiol et al.

    Comparison of human papillomavirus type 18 (HPV-18) E6-mediated degradation of p53 in vitro and in vivo reveals significant differences based on p53 structure and cell type but little difference with respect to mutants of HPV-18 E6

    J Gen Virol

    (1998)
  • M Lechner et al.

    Human papillomavirus E6 proteins bind p53 in vivo and abrogate p53-mediated repression of transcription

    EMBO J

    (1992)
  • M Lechner et al.

    Inhibition of p53 DNA binding by human papillomavirus E6 proteins

    J Virol

    (1994)
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