Regular ArticleAge-Dependent Effects of Secreted Semaphorins 3A, 3F, and 3E on Developing Hippocampal Axons: In Vitro Effects and Phenotype of Semaphorin 3A (−/−) Mice
References (70)
- et al.
Development of commissural connections in the hippocampus of reeler mice: Evidence of an inhibitory influence of Cajal-Retzius cells
Exp. Neurol.
(1999) - et al.
Many major CNS axon projections develop normally in the absence of Semaphorin III
Mol. Cell. Neurosci.
(1998) - et al.
Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the Semaphorins Sema E and Sema IV but not Sema III
Neuron
(1997) - et al.
Semaphorin-Neuropilin interactions underlying sympathetic axon responses to class III Semaphorins
Neuron
(1998) - et al.
Functions of netrins and Semaphorins in axon guidance
Curr. Opin. Neurobiol.
(1996) - et al.
Different primary target cells are important for fiber lamination in the fascia dentata: A lesson from reeler mutant mice
Exp. Neurol.
(1999) - et al.
Secreted chick Semaphorins bind recombinant neuropilin with similar affinities but bind different subsets of neurons in situ
Neuron
(1997) - et al.
Neuropilin-2 is a receptor for Semaphorin IV: Insight into structural basis of receptor function and specificity
Cell
(1998) - et al.
Neuropilin-2 is required in vivo for selective axon guidance responses to secreted semaphorin
Neuron
(2000) - et al.
Neuropilin is a receptor for the axonal chemorepellent Semaphorin III
Cell
(1997)
Growth cones and the cues that repel them
Trends Neurosci.
Neuropilin is a Semaphorin III Receptor
Cell
Collapsin: A protein in brain that induce the collapse and paralysis of neuronal growth cones
Cell
Semaphorin III can function as a selective chemorepellent to pattern sensory projections in the spinal cord
Neuron
Mouse Semaphorin H inhibits neurite outgrowth from sensory neurons
Neurosci. Res.
Developmental localization of Semaphorin H messenger RNA acting as a collapsing factor on sensory axons in the mouse brain
Neuroscience
Regulation of Semaphorin III/Collapsin-1 gene expression during peripheral nerve generation
J. Comp. Neurol.
Murine Semaphorin D/Collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension
Neuron
Semaphorins and their receptors in vertebrates and invertebrates
Curr. Opin. Neurobiol.
Neuropilin-1 is expressed on adult mammalian dorsal root ganglion neurons and mediates Semaphorin 3A/collapsin-1-induced growth cone collapse by small diameter sensory afferents
Mol. Cell. Neurosci.
Genomic organization of human neuropilin-1 and neuropilin-2 genes: Identification and distribution of splice variants and soluble isoforms
Genomics
Mouse Semaphorin H induces PC12 cell neurite outgrowth activating Ras-mitogen-activated protein kinase signaling pathway via Ca2+ influx
J. Biol. Chem.
The distribution of collapsin-1 mRNA in the developing chicken nervous system
Dev. Biol.
Target- and maturation-specific membrane associated molecules determine the ingrowth of entorhinal fibers into the hippocampus
Dev. Biol.
Sema3C and Netrin-1 differentially affect axon growth in the hippocampal formation
Mol Cell. Neurosci.
Plexin-neuropilin-1 complexes form functional Semaphorin-3A receptors
Cell
Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored Semaphorins in vertebrates
Cell
Motor axon subpopulations respond differentially to the chemorepellents Netrin-1 and Semaphorin D
Neuron
The chemorepulsive activity of secreted Semaphorins is regulated by furin-dependent proteolytic processing
EMBO J.
Hippocampal formation
Semaphorins act as attractive and repulsive guidance signal during the development of cortical projections
Development
Semaphorin III is needed for normal patterning and growth of nerve, bones and heart
Nature
Aberrant development of hippocampal circuits and altered neuronal activity in netrin-1-deficient mice
Development
Reelin regulates the development and synaptogenesis of the layer-specific entorhino-hippocampal connections
J. Neurosci.
Cited by (74)
The chemorepellent draxin is involved in hippocampal mossy fiber projection
2018, Biochemical and Biophysical Research CommunicationsCitation Excerpt :In contrast, entorhinal fibers project to the outer part of the molecular layer in the DG and the most distal part of apical dendrites in CA3 (the stratum lacunosum-moleculare: SLM). Previous studies implicate several axon guidance molecules in targeting innervation of afferents in the hippocampus [2–15]. Furthermore, it is known that semaphorins Sema6A and 6B, and their receptors plexinA2 and A4, have crucial roles in regulating mossy fiber projection [16,17].
In vitro models of axon regeneration
2017, Experimental NeurologyProlyl Isomerase Pin1 Regulates Axon Guidance by Stabilizing CRMP2A Selectively in Distal Axons
2015, Cell ReportsCitation Excerpt :Similarly, Pin1 KO spinal nerves in the cervical region also exhibited stunted and less branched projections (two out of four Pin1 KO embryos and none out of four Pin1 WT) (Figures 6E–6H). Next, to characterize the role of Pin1 in development of the CNS, we analyzed entorhino-hippocampal projections (Gu et al., 2003; Pozas et al., 2001) by staining horizontal sections of E15.5 embryonic brains with neurofilament antibodies as a marker. While the entorhinal perforant pathway projections in Pin1 heterozygous embryos at E15.5 had already reached stratum lacunosum-moleculare of the developing hippocampus proper, growth of the Pin1 KO entorhinal projections was significantly slower, reaching the border of subiculum (Figures 6I–6M, three out of three Pin1 KO embryos, none out of three Pin1+/−), which is consistent with the reduced axon growth (Figure 4) and increased sensitivity to Sema3A (Figure 5) of Pin1 KO neurons.
Antagonistic Effects of BACE1 and APH1B-γ-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse
2015, Cell ReportsCitation Excerpt :It is intriguing that two proteases, β- and γ-secretase, so closely involved in the pathogenesis of AD, also appear to coordinately regulate a physiological process of axonal guidance. Although the functional role of Sema3A and CHL1 in the adult brain is not clearly established, it is tempting to speculate that the continued release and expression of these molecules in hippocampus and olfactory bulb, where synaptic plasticity is highly dynamic, is important for modulation and maintenance of brain circuits in adult CNS (Pozas et al., 2001; Sahay et al., 2005). Genetic deficiency of BACE1 and CHL1 affects circuitry in the adult olfactory bulb and/or hippocampus (Cao et al., 2012; Hitt et al., 2012; Rajapaksha et al., 2011), and we find that Sema3A-induced growth cone collapse is also altered in hippocampal neurons treated with BACE1 or γ-secretase inhibitors (Figure S4).
Increased smooth muscle contractility in mice deficient for neuropilin 2
2012, American Journal of Pathology
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