Regular ArticleNGF Binding to p75 Enhances the Sensitivity of Sensory and Sympathetic Neurons to NGF at Different Stages of Development
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2014, Handbook of Clinical NeurologyCitation Excerpt :The Trks exhibit some selectivity in their preference for neurotrophin binding – NGF binds selectively to TrkA, BDNF and NT-4/5 to TrkB, and NT-3 preferentially to TrkC, but can also activate TrkB and TrkA at higher concentrations (Lu et al., 2005; Reichardt, 2006). Both p75NTR and Trk receptors can function individually, but they are often coexpressed where they form complexes (i.e., p75NTR and Trks) that have a higher affinity for the neurotrophin than the receptors individually, allowing the neurotrophin to act at lower concentrations and potentiating the signaling response (Hempstead et al., 1991; Horton et al., 1997; Bibel et al., 1999). NT-3/TrkA interactions may be the exception to this rule as the presence of p75 results in reduced activation of TrkA by NT-3 (Mischel et al., 2001).
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The first two authors contributed equally to this work.