Elsevier

Journal of Autoimmunity

Volume 19, Issue 3, November 2002, Pages 155-160
Journal of Autoimmunity

Regular Articles
Autoantibodies to C-reactive Protein is a Common Finding in SLE, but not in Primary Sjögren's Syndrome, Rheumatoid Arthritis or Inflammatory Bowel Disease

https://doi.org/10.1006/jaut.2002.0608Get rights and content

Abstract

The occurrence of antibodies to human C-reactive protein (CRP) was analysed by enzyme-linked immunosorbent assay (ELISA) in 56 patient sera known to contain antibodies to double-stranded DNA (dsDNA) and in 16 sera from patients with primary Sjögren's syndrome (SS), 15 rheumatoid arthritis, 31 Crohn's disease, and 37 ulcerative colitis. Eighty-seven per cent of the patients with anti-dsDNA antibodies had systemic lupus erythematosus (SLE) and the remaining had autoimmune hepatitis. The cut-off for positive anti-CRP test was set at the 95th percentile of 100 healthy blood donors. Twenty of 56 anti-dsDNA sera (36%) and two of 16 SS sera (13%) had antibodies reactive with human CRP, whereas all other samples were negative. Thirteen of 27 SLE patients (48%) were positive on at least one occasion. The sera containing anti-CRP antibodies only reacted with surface-bound antigen, but not with native CRP in solution. In conclusion, we found that autoantibodies to CRP are common in sera from patients with anti-dsDNA antibodies. It is not likely that this explains the relative failure of CRP response in patients with active SLE. However, it cannot be excluded that anti-CRP autoantibodies have other biological potentials of pathophysiological interest in SLE, for instance by binding to CRP deposited on cell and tissue surfaces.

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    Correspondence to: Christopher Sjöwall, MSc., Rheumatology Unit, University Hospital of Linköping, S-581 85 Linköping, Sweden. Tel.: +46 13 222000; Fax: +46 13 221801; E-mail: [email protected]

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